Targeting the PAC1 Receptor for Neurological and Metabolic Disorders.

Targeting the PAC1 Receptor for Neurological and Metabolic Disorders. Curr Top Med Chem. 2019 Jul 08;: Authors: Liao C, de Molliens MP, Schneebeli ST, Brewer M, Song G, Chatenet D, Braas KM, May V, Li J Abstract The pituitary adenylate cyclase-activating polypeptide (PACAP)-selective PAC1 receptor (PAC1R, ADCYAP1R1) is a member of the vasoactive intestinal peptide (VIP)/secretin/glucagon family of G protein-coupled receptors (GPCRs). PAC1R has been shown to play crucial roles in the central and peripheral nervous systems. The activation of PAC1R initiates diverse downstream signal transduction pathways, including adenylyl cyclase, phospholipase C, MEK/ERK and Akt pathways that regulate a number of physiological systems to maintain functional homeostasis. Accordingly, at times of tissue injury or insult, PACAP/PAC1R activation of these pathways can be trophic to blunt or delay apoptotic events and enhance cell survival. Enhancing PAC1R signaling under these conditions has the potential to mitigate cellular damages associated with cerebrovascular trauma (including stroke), neurodegeneration (such as Parkinson's and Alzheimer's disease) or peripheral organ insults. Conversely, maladaptive PACAP/PAC1R signaling has been implicated in a number of disorders, including stress-related psychopathologies (i.e., depression, posttraumatic stress disorder, and related abnormalities), chronic pain and migraine, and metabolic diseases; abrogating PAC1R signaling under ...
Source: Current Topics in Medicinal Chemistry - Category: Chemistry Authors: Tags: Curr Top Med Chem Source Type: research

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ConclusionOnly a few cases of penile FG have been reported. Early debridement of all necrotic tissue is the golden rule.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
Wanted your opinions on your management. If you have someone come in with mild pancreatitis unknown etiology (full work up normal) with no abnormal labs other than the lipase being>5000. Vitals stable. APACHE II on admission 3. And patient wants to eat the next day with pain improved despite lipase being still>5000. Would you initiate early refeeding or would you wait a while?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Internal Medicine and IM Subspecialties Source Type: forums
Question: Are we diluting the prestige and value of ACGME-accredited Pain fellowships by allowing alternative venues of interventional training? https://www.spine.org/Portals/0/Assets/Downloads/Education/ISMMFellowshipDirectory.pdf "WHAT DISTINGUISHES NASS ISMM FELLOWSHIPS FROM PAIN FELLOWSHIPS? The primary focus of NASS-recognized ISMM fellowships is the clinical assessment and treatment of patients with spine and musculoskeletal conditions. The fellowships... New NASS-approved vs ACGME-accredited Spine/Pain Fellowships?
Source: Student Doctor Network - Category: Universities & Medical Training Authors: Tags: Pain Medicine Source Type: forums
Publication date: Available online 10 August 2019Source: Annals of Physical and Rehabilitation MedicineAuthor(s): M. Compagnat, S. Mandigout, C.S. Batcho, N. Vuillerme, J.Y. Salle, R. David, J.C. DavietAbstractBackgroundRecent studies reported that wearable sensor devices show low validity for assessing the amount of energy expenditure in individuals after stroke.ObjectiveWe aimed to evaluate the validity of energy expenditure calculation based on the product of energy cost and walked distance estimated by wearable devices in individuals after hemispheric stroke.MethodsWe recruited individuals with hemispheric stroke seque...
Source: Annals of Physical and Rehabilitation Medicine - Category: Rehabilitation Source Type: research
Publication date: Available online 17 August 2019Source: Trends in Cognitive SciencesAuthor(s): Erdem Pulcu, Michael BrowningOur knowledge about the state of the world is often incomplete, making it difficult to select the best course of action. One strategy that can be used to improve our ability to make decisions is to identify the causes of our ignorance (i.e., why an unexpected event might have occurred) and use estimates of the uncertainty induced by these causes to guide our learning. Here, we explain the logic behind this process and describe the evidence that human learners use estimates of uncertainty to sculpt th...
Source: Trends in Cognitive Sciences - Category: Psychiatry & Psychology Source Type: research
Publication date: Available online 18 August 2019Source: Aggression and Violent BehaviorAuthor(s): Bushra Sabri, Claire Greene, Gregory M. LucasAbstractViolence victimization is common among men and women who use substances and is associated with co-occurring health issues such as PTSD, depression and HIV. Substance use interventions, therefore, should include integrated components that are designed to address co-occurring health issues among victimized substance-using individuals. This systematic review synthesized the evidence on efficacy of comprehensive, integrated, multicomponent interventions for victimized substance...
Source: Aggression and Violent Behavior - Category: Psychiatry & Psychology Source Type: research
ConclusionThe incidence of early poststroke seizures was overall rare, and no significant differences emerged between patients receiving and those not receiving reperfusion therapies.This article is part of the Special Issue “Seizures and Stroke”.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
Publication date: September–October 2019Source: Brain Stimulation, Volume 12, Issue 5Author(s): Anca Velisar, Helen Bronte-Stewart
Source: Brain Stimulation - Category: Neurology Source Type: research
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Source: Alzheimer's and Dementia: The Journal of the Alzheimer's Association - Category: Geriatrics Source Type: research
Authors: Zhang RT, Zhou HY, Wang YM, Yang ZY, Wang Y, So SH, Chiu CD, Leung PWL, Cheung EFC, Chan RCK Abstract Schizotypal personality (SP) traits have been found to be correlated with autistic traits, obsessive-compulsive traits, depressive symptoms and anxiety symptoms. However, the overall pattern of the relationship remains unclear. The purpose of this study was to investigate the network structure between SP traits and other subclinical features (symptoms or traits) and test the replicability of these relationships. A total of 2204 college students completed measurements for SP traits, autistic traits, obsessi...
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
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