Tris(8-Hydroxyquinoline)iron induces apoptotic cell death via oxidative stress and by activating death receptor signaling pathway in human head and neck carcinoma cells

ConclusionThis study is the first to suggest that apoptosis mediates the anti-HNSCC of Feq3. Feq3 has potential as a cancer therapeutic agent against HNSCC.Graphical abstractThe signaling pathways of tris-(8-hydroxyquinoline) iron induces the apoptotic cell death via cell cycle arrest, oxidative stress, intrinsic mitochondrial pathway and extrinsic death receptor signaling pathway activation in HNSCC cells.
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research