Molecules, Vol. 24, Pages 2287: Preventive Effect of Quercetin in a Triple Transgenic Alzheimer ’s Disease Mice Model
In this study, we evaluated the effect of chronic oral quercetin administration (100 mg/kg) on neurodegeneration markers and cognitive and emotional deficits in a triple transgenic Alzheimer’s disease (3xTg-AD) mouse model using histological and behavioral analyses. Our results suggest that long-term (12 months) oral preventive treatment with quercetin has significant effects on β-amyloidosis reduction and tends to decrease tauopathy in the hippocampus and amygdala. These decreases positively affected the cognitive functional recovery (without modifying the emotional skills) of 3xTg-AD mice. These findings suggest that preventive and chronic administration of Qc might help to delay the development of histopathological hallmarks and cognitive function deficits in AD.
Source: Molecules - Category: Chemistry Authors: P érez-Corredor Paula Sabogal-Gu áqueta Angelica Maria Carrillo-Hormaza Luis Cardona-G ómez Gloria Patricia Tags: Article Source Type: research
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