18F-FDG PET/CT as non-inasive tool to assess transplanted pancreas graft rejection

436Aim: Currently, there are no available tool able to non-invasively define the presence of transplanted pancreas graft rejection; therefore, graft biopsy is nowadays the only available diagnostic tool for pancreas graft rejection. The aim of the present study is to assess the role of 18F-FDG PET-CT in detecting and monitoring pancreas graft rejection. Materials and Methods: Retrospective study including 12 patients (6M and 6F; mean age at transplant: 45±12 yrs; mean duration of diabetes 24±11yrs) who underwent pancreas transplantation alone (PTA) or simultaneous pancreas-kidney transplant (SPK) in the past. Mean duration of diabetes was 24±11 yrs. 18F-FDG PET/CT was performed in all patients according to the following clinical indications: i) suspicion of pancreas graft rejection (n=9) based on hyperglycemia, abdominal pain and/or high serum amilase/lipase; ii) suspected lymphoproliferative disease (n=1); iii) oncological follow-up (1 melanoma and 1 solitary lung nodule). The cohort included patients suspected for acute pancreas graft rejection (REJ, based on graft biopsy and/or presence of donor-specific antibodies; n=9) and control patients with no rejection. A subgroup of patients (n=4) underwent to a further follow-up 18F-FDG PET/CT after treatment of graft rejection. PET/CT images were interpreted qualitatively (focal, diffuse homogenous, diffuse non-homogeneous; Visual scale: 0= no uptake or less than the liver; 1=liver uptake; 2>liver uptake) ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: NETs, BAT and All That Source Type: research

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Source: Materials Letters - Category: Materials Science Source Type: research
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