Molecules, Vol. 24, Pages 1142: Advances in Molecular Mechanisms of Wheat Allergenicity in Animal Models: A Comprehensive Review

Molecules, Vol. 24, Pages 1142: Advances in Molecular Mechanisms of Wheat Allergenicity in Animal Models: A Comprehensive Review Molecules doi: 10.3390/molecules24061142 Authors: Yining Jin Harini G. Acharya Devansh Acharya Rick Jorgensen Haoran Gao James Secord Perry K. W. Ng Venugopal Gangur The prevalence of wheat allergy has reached significant levels in many countries. Therefore, wheat is a major global food safety and public health issue. Animal models serve as critical tools to advance the understanding of the mechanisms of wheat allergenicity to develop preventive and control methods. A comprehensive review on the molecular mechanisms of wheat allergenicity using animal models is unavailable at present. There were two major objectives of this study: To identify the lessons that animal models have taught us regarding the molecular mechanisms of wheat allergenicity and to identify the strengths, challenges, and future prospects of animal models in basic and applied wheat allergy research. Using the PubMed and Google Scholar databases, we retrieved and critically analyzed the relevant articles and excluded celiac disease and non-celiac gluten sensitivity. Our analysis shows that animal models can provide insight into the IgE epitope structure of wheat allergens, effects of detergents and other chemicals on wheat allergenicity, and the role of genetics, microbiome, and food processing in wheat allergy. Although animal models have inherent limitations...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research

Related Links:

We describe the case of a 16-year-old boy with a medical history of allergic asthma, celiac disease, and known food-induced allergy for fish, fresh milk, peanuts, hazelnuts, walnuts, apples, kiwis, and peaches. Acute onset of dyspnea followed by cyanosis of the lips and respiratory failure was described immediately after having an ice cream sandwich. Unsuccessful rescues were immediately attempted with oral administration of betamethasone, intramuscular injection of adrenaline, and cardiopulmonary resuscitation. A complete post-mortem examination was performed. Serum dosage of mast cell beta-tryptase from femoral blood det...
Source: International Journal of Immunopathology and Pharmacology - Category: Allergy & Immunology Tags: Int J Immunopathol Pharmacol Source Type: research
Title: Exposing Babies to Wheat Very Early Might Prevent Celiac Disease: StudyCategory: Health NewsCreated: 9/29/2020 12:00:00 AMLast Editorial Review: 9/30/2020 12:00:00 AM
Source: MedicineNet Allergies General - Category: Allergy & Immunology Source Type: news
The IgG antibody response to gluten is different in people with celiac disease and non-celiac gluten sensitivity, respectively, researchers report.Reuters Health Information
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Gastroenterology News Source Type: news
Source: Critical Reviews in Food Science and Nutrition - Category: Nutrition Authors: Source Type: research
AbstractPurpose of ReviewFunctional dyspepsia (FD) is a chronic functional gastrointestinal disorder characterised by upper gastrointestinal symptoms. Here, we aimed to examine the evidence for immune responses to food in FD and overlap with food hypersensitivity conditions.Recent FindingsA feature of FD in a subset of patients is an increase in mucosal eosinophils, mast cells, intraepithelial cytotoxic T cells and systemic gut-homing T cells in the duodenum, suggesting that immune dysfunction is characteristic of this disease. Rates of self-reported non-celiac wheat/gluten sensitivity (NCW/GS) are higher in FD patients. F...
Source: Current Gastroenterology Reports - Category: Gastroenterology Source Type: research
Purpose of review Noncoeliac gluten sensitivity (NCGS) can be suspected after exclusion of coeliac disease and wheat allergy. However, poorly understood pathogenesis of the NCGS, lack of gold standard for diagnosis and agreement in the definition for the NCGS condition, open the space for future investigation. This review aims to give an overview on the diagnosis and effective diet composition in the treatment of NCGS symptoms. Recent findings It appears that a diet low in fermentable oligo, di, and monosaccharides and polyols (FODMAPs) and gluten-free diet play a prominent role in the strategy of NCGS management. Con...
Source: Current Opinion in Clinical Nutrition and Metabolic Care - Category: Nutrition Tags: NUTRITION AND THE GASTROINTESTINAL TRACT: Edited by M. Isabel T.D. Correia and André Van Gossum Source Type: research
I do not have to stress how important a role food and eating play in our lives. Food is at the base in Maslow’s hierarchy of our needs; it is essential for our survival. It shows perfectly the creativity of humankind: food exists in the richest variety of ingredients, forms, shapes, tastes and colors all over the world from the Greenlandic kiviak (dozens of small birds stuffed into a seal fermented under a rock) through the Liquid Pea Sphere of molecular gastronomy to the tagliatelle with hand-cut meat ragout from the world’s best restaurant, Osteria Francescana. The advent of novel digital health tools will ra...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Future of Food 3d printing genomics Innovation technology GC1 sensors nutrigenomics food sensors Source Type: blogs
If I had to name which futuristic healthcare innovations are the easiest to put into practice now that can really make a difference in people’s lives today, I’d say one of those is definitely at-home testing. To have access to a wide range of analyses determining our lab markers and blood results without the wait at the doctor’s, at the lab, and without even meeting anyone… Sounds great. Not to mention that it’s already in the existing testing kits. We just need to use all these in a more systematic way. Pregnancy tests or finger-prick diabetes tests, for example, were game changers. They ...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: E-Patients Future of Medicine Health Insurance Robotics Telemedicine & Smartphones blood test fda genetics theranos food scanner national geographic food allergy Nima microbiome test at-home tests lab test foodmarble Iama Source Type: blogs
Celiac disease (CD), triggered by the ingestion of gluten, occurs in people genetically predisposed to develop the chronic autoimmune condition. During the past few decades, doctors have learned much about how the disease develops, including genetic and other risk factors. However, results from studies on whether people with CD have an increased risk of premature death linked to the condition have been mixed. A recent study shows a small but statistically significant increased mortality rate. Celiac disease can affect the entire body Until recently, CD was considered a mainly pediatric gastrointestinal disorder, associated...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Allergies Autoimmune diseases Source Type: blogs
CONCLUSIONS: Although carried out on a small number of patients, our pilot trial leads us to conclude that a combined strategy of naturally gluten-free diet therapy with administration of the probiotic strain ES1 appears to offer a greater advantage than the dietary regime alone in improving the clinical symptomatic picture and in stabilizing the intestinal microbiota. PMID: 32397695 [PubMed - as supplied by publisher]
Source: Minerva Gastroenterologica e Dietologica - Category: Gastroenterology Tags: Minerva Gastroenterol Dietol Source Type: research
More News: Allergy | Allergy & Immunology | Celiac Disease | Chemistry | Coeliac Disease | Databases & Libraries | Genetics | Gluten | International Medicine & Public Health | Lessons | Study | Vaccines | Veterinary Vaccinations | Wheat