Molecules, Vol. 24, Pages 586: The Drug Candidate BGP-15 Delays the Onset of Diastolic Dysfunction in the Goto-Kakizaki Rat Model of Diabetic Cardiomyopathy

Conclusions: Even though the BGP-15-treatment did not interfere significantly with glucose homeostasis and vascular status, it considerably enhanced diastolic function, by affecting the SERCA/phospholamban pathway in GotoK rats. Although it requires further investigation, BGP-15 may offer a new therapeutic approach in DCM.

Source: Molecules - February 7, 2019 Category: Chemistry Authors: Mariann Bombicz Daniel Priksz Rudolf Gesztelyi Rita Kiss Nora Hollos Balazs Varga Jozsef Nemeth Attila Toth Zoltan Papp Zoltan Szilvassy Bela Juhasz Tags: Article Source Type: research