IJERPH, Vol. 16, Pages 326: The Risk of Stroke in Kidney Transplant Recipients with End-Stage Kidney Disease

IJERPH, Vol. 16, Pages 326: The Risk of Stroke in Kidney Transplant Recipients with End-Stage Kidney Disease International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16030326 Authors: Shih-Ting Huang Tung-Min Yu Ya-Wen Chuang Mu-Chi Chung Chen-Yu Wang Pin-Kuei Fu Tai-Yuan Ke Chi-Yuan Li Cheng-Li Lin Ming-Ju Wu Chia-Hung Kao Background: The incidence of stroke after kidney transplantation is poorly understood. Our study aimed to determine the incidence and predictors of stroke as well as mortality from stroke in kidney transplant recipients (KTRs). Methods: This retrospective cohort study used the National Health Insurance Research Database in Taiwan to study KTRs (N = 4635), patients with end-stage renal disease (ESRD; N = 69,297), and patients from the general population who were chronic kidney disease (CKD)-free and matched by comorbidities (N = 69,297) for the years 2000 through 2010. The risk of stroke was analyzed using univariate and multivariate Cox regression models and compared between study cohorts. Findings: Compared with the ESRD subgroup, KTRs had a significantly lower risk of overall stroke (adjusted hazard ratio (aHR) = 0.37, 95% confidence interval (CI) = 0.31–0.44), ischemic stroke (aHR = 0.45, 95% CI = 0.37–0.55), and hemorrhagic stroke (aHR = 0.20, 95% CI = 0.14–0.29). The risk patterns for each type of stroke in the KTR group were not significantly different t...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research