AK002, a Novel Humanized Monoclonal Antibody to Siglec-8, Inhibits Mast Cell Activity and Depletes Eosinophils in Ex Vivo Bone Marrow Tissue from Patients with Systemic Mastocytosis

CONCLUSIONS: Bone marrow aspirates from patients with SM had activated mast cells and eosinophils that displayed robust expression of Siglec-8. AK002 demonstrated SM mast cell inhibition in ex vivo bone marrow aspirates. AK002 also had depleting effects on eosinophils, which may be valuable to SM patients with associated eosinophilia. These encouraging results could represent a novel approach for the treatment of SM.DisclosuresYoungblood: Allakos, Inc.: Employment. Brock: Allakos, Inc.: Employment. Leung: Allakos, Inc.: Employment. Chang: Allakos, Inc.: Employment. Bebbington: Allakos, Inc.: Employment. Tomasevic: Allakos, Inc.: Employment.

Source: Blood - November 21, 2018 Category: Hematology Authors: Youngblood, B. A., Brock, E. C., Leung, J., Chang, A. T., Bebbington, C., Tomasevic, N. Tags: 201. Granulocytes, Monocytes, and Macrophages: Poster I Source Type: research