Albiglutide and cardiovascular outcomes in patients with type 2 diabetes and cardiovascular disease (Harmony Outcomes): a double-blind, randomised placebo-controlled trial
This study is registered with ClinicalTrials.gov, number NCT02465515.FindingsPatients were screened between July 1, 2015, and Nov 24, 2016. 10 793 patients were screened and 9463 participants were enrolled and randomly assigned to groups: 4731 patients were assigned to receive albiglutide and 4732 patients to receive placebo. On Nov 8, 2017, it was determined that 611 primary endpoints and a median follow-up of at least 1·5 years had accrued, and participants returned for a final visit and discontinuation from study treatment; the last patient visit was on March 12, 2018. These 9463 patients, the intention-to-treat population, were evaluated for a median duration of 1·6 years and were assessed for the primary outcome. The primary composite outcome occurred in 338 (7%) of 4731 patients at an incidence rate of 4·6 events per 100 person-years in the albiglutide group and in 428 (9%) of 4732 patients at an incidence rate of 5·9 events per 100 person-years in the placebo group (hazard ratio 0·78, 95% CI 0·68–0·90), which indicated that albiglutide was superior to placebo (p
ConclusionsFindings suggest that self-harm behavior and psychiatric disorders are associated with increased ED utilization for subsequent chronic disease-related ED utilization. Chronic disease among adolescent psychiatric patients should be attended to, potentially involving new models of clinical follow-up care.
CONCLUSIONS: In coronary bifurcation lesions with a large SB, POT may be beneficial to improve long-term clinical outcome, particularly in patients treated without kissing ballooning during the procedure. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT01642992. PMID: 30891962 [PubMed - as supplied by publisher]
CONCLUSIONS: Although aspirin increased the amount of chest tube drainage, it was not associated with increased risk of re-operation for bleeding. In addition, the risks of early postoperative all-cause mortality and MI were not reduced by using preoperative aspirin. PMID: 30891961 [PubMed - as supplied by publisher]
Authors: Jeong HS, Hong SJ PMID: 30891965 [PubMed - as supplied by publisher]
Conclusions: The TMST has been widely used since first introduced, albeit not always as originally described. There is considerable evidence for the validity of the test, but its reliability and responsiveness are not yet firmly established.
In this study, to estimate the states that are not directly available from the Bergman minimal model a high-order sliding mode observer is proposed. Then fractional calculus is combined with sliding mode control (SMC) for blood glucose regulation to create more robustness performance and make more degree of freedom and flexibility for the proposed method. Then an adaptive fractional-order SMC is proposed. The adaptive SMC protect controller against disturbance and uncertainties while the fractional calculus provides robust performance. Numerical simulation verifies that the proposed controllers have better performance in t...
This paper deals with the design of robust observer based output feedback control law for the stabilisation of an uncertain nonlinear system and subsequently apply the developed method for the regulation of plasma glucose concentration in Type 1 diabetes (T1D) patients. The principal objective behind the proposed design is to deal with the issues of intra-patient parametric variation and non-availability of all state variables for measurement. The proposed control technique for the T1D patient model is based on the attractive ellipsoid method (AEM). The observer and controller conditions are obtained in terms of linear mat...
[Guardian] Researchers are unanimous that talc or talcum powder can cause lung, ovarian, stomach and endometrial (uterine) cancers. They said talc consisting of asbestos is generally accepted as being able to cause cancer if it is inhaled or/and used regularly in the genital area. Evidence on asbestos-free talc is however less clear.
Could a simple blood test catch cancer before symptoms appear?Nicola Davis goes beyond the hype and investigates the future of blood diagnostics and cancerA blood test that could detect cancer earlier than current methods has long been a dream of oncologists. The hope is that these “liquid biopsies” could save countless lives by diagnosing cancer before symptoms show. They’re less invasive, quicker and easier than what is available now.However, this area of research has been plagued with hype. This happened most notably when a Silicon Valley startup –Theranos– allegedlyduped investors out of h...
Huazhang Wu, Fengchang Qiao, Yunli Zhao, Shouwei Wu, Minjie Hu, Tao Wu, Fuxin Huang, Wenjing Chen, Dengzhong Sun, Mulin Liu, Jinsong Zhao