Invasive aspergillosis in patients admitted to the intensive care unit with severe influenza: a retrospective cohort study

In this study, influenza was found to be independently associated with invasive pulmonary aspergillosis (adjusted odds ratio 5·19; 95% CI 2·63–10·26; p<0·0001), along with a higher APACHE II score, male sex, and use of corticosteroids.InterpretationInfluenza was identified as an independent risk factor for invasive pulmonary aspergillosis and is associated with high mortality. Future studies should assess whether a faster diagnosis or antifungal prophylaxis could improve the outcome of influenza-associated aspergillosis.FundingNone.
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research