Incorporating machine learning approaches to assess putative environmental risk factors for multiple sclerosis

Conclusions While this finding requires confirmation, it is interesting given the association between pesticide exposure and other neurological diseases. The study also demonstrates the application of LASSO to identify environmental exposures with reduced multiple statistical testing penalty. Machine learning approaches may be useful for future investigations of concomitant MS risk or prognostic factors.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research

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We report herein a case of bloodstream infection due to LM in a 25-year-old woman with MS treated with alemtuzumab. We searched the UMC/WHO Vigibase system for all reported cases of LM in patients treated with alemtuzumab and found 29 cases overall up to 21 July 2019. We also performed a literature review of MS cases with LM on alemtuzumab, in order to evaluate epidemiology, clinical characteristics, and outcome of this complication. Since the published cases (N=8) were mainly reported in recent years but more cases were found in the UMC/WHO Vigibase system (although not necessarily in patients with MS), we hypothesize tha...
Source: Infezioni in Medicina - Category: Infectious Diseases Tags: Infez Med Source Type: research
A review of FDA reports also shows notably higher rates of shingles in women among younger patients taking disease-modifying therapies for multiple sclerosis.Medscape Medical News
Source: Medscape Allergy Headlines - Category: Allergy & Immunology Tags: Neurology & Neurosurgery News Source Type: news
CONCLUSION: The results of this experiment suggest the possibility of swimming exercise in urological diseases that are difficult to treat. Swimming exercises can be considered for relief of symptom in incurable multiple sclerosis. PMID: 32482056 [PubMed]
Source: International Neurourology Journal - Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research
Authors: Gurpinar B, Kara B, Idiman E Abstract OBJECTIVES: Postural control and hand dexterity are significantly impaired in people with multiple sclerosis (pwMS). Aquatic interventions may have additional benefits in the treatment of pwMS. The purpose of this study is to compare the effects of two different aquatic exercises on postural control and hand function. METHODS: Thirty pwMS, relapsing-remitting type were randomly divided into a Halliwick (Hallw) and an Aquatic Plyometric Exercise (APE) group. The Limits of Stability test was used to evaluate postural control using the Biodex Balance System. The Nine-...
Source: Journal of Musculoskeletal Neuronal Interactions - Category: Neurology Tags: J Musculoskelet Neuronal Interact Source Type: research
Condition:   Multiple Sclerosis Intervention:   Behavioral: Recumbent Stepping, High-Intensity Interval Training Sponsors:   Berry College;   University of Alabama at Birmingham Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Contributors : Wei Guo ; Wen Lei ; Zhengying BianSeries Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Mus musculusTo explore the potential roles of lncRNAs in the progress of multiple sclerosis, spleens of experimental autoimmune encephalomyelitis (EAE) model mice and normal mice were used as the samples to obtain the expression profiles of lncRNAs and mRNAs with the mouse LncRNA Array v3.0.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Non-coding RNA profiling by array Mus musculus Source Type: research
We present a case with a close temporal association of the first diagnosis of multiple sclerosis and stress cardiomyopathy.
Source: BMC Neurology - Category: Neurology Authors: Tags: Case report Source Type: research
imeni Vozza Multiple sclerosis (MS) is an autoimmune disease in which the immune system reacts by damaging the central nervous system, specifically myelin and oligodendrocytes. It is the most debilitating neurological disease among young adults, causing personal, familiar, social, and professional limitations. Multiple sclerosis can cause disturbances in the orofacial district, due to a demyelination process on the nerves of the head and neck district. The aim of this study was to evaluate the oral health status, dysphagia, and quality of life of patients affected by MS. For this study, 101 patients aged between 12 ...
Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
In this study, we focused on interhemispheric connections as previous research has shown links between anatomical homologous connections and cognition. We examined functional interhemispheric connectivity (IC) in MS during resting-state functional MRI using both stationary and dynamic strategies and related connectivity measures to processing speed performance. Twenty-five patients with relapsing-remitting MS and 41 controls were recruited. Stationary functional IC was assessed between homologous Regions of Interest (ROIs) using correlation. For dynamic IC, a sliding window approach was used to quantify changes between hom...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Conclusion: Our pilot results support that vigorous treadmill training can potentially improve neuroplastic potential and mitigate symptoms of the disease even among people who have accumulated substantial disability due to MS.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
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