P-236Clinical and pathological features in colorectal cancer associated to Lynch syndrome

Introduction: Lynch syndrome (LS) is the most common cause of inherited colorectal cancer (CRC) and accounts for approximately 3 percent of newly diagnosed cases of CRC. Lynch syndrome is an autosomal dominant disorder that is caused by a germline mutation in one of several DNA mismatch repair genes (MLH1, MSH2, MSH6 and PMS2) or loss of expression of MSH2 due to deletion in the EPCAM gene (previously called TACSTD1). It is characterized by an increased risk for colorectal cancer (CRC) and cancers of the endometrium, stomach, ovary, small bowel, hepatobiliary tract, urinary tract, brain, and skin. CRCs in Lynch syndrome differ from sporadic CRCs.
Source: Annals of Oncology - Category: Cancer & Oncology Source Type: research