Computation of reliable textural indices from multimodal brain MRI: suggestions based on a study of patients with diffuse intrinsic pontine glioma.

Computation of reliable textural indices from multimodal brain MRI: suggestions based on a study of patients with diffuse intrinsic pontine glioma. Phys Med Biol. 2018 Apr 10;: Authors: Goya-Outi J, Orlhac F, Calmon R, Alentorn A, Nioche C, Philippe C, Puget S, Boddaert N, Buvat I, Grill J, Frouin V, Frouin F Abstract Few methodological studies regarding widely used textural indices robustness in MRI have been reported. In this context, this study aims at proposing some rules to compute reliable textural indices from multimodal 3D brain MRI. Diagnosis and post-biopsy MR scans including T1, post-contrast T1, T2 and FLAIR images from thirty children with diffuse intrinsic pontine glioma (DIPG) were considered. The Hybrid White Stripe method was adapted to standardize MR intensities. Sixty textural indices were then computed for each modality in different regions of interest, including tumor and white matter (WM). Three types of intensity binning were compared d<sub>i</sub>: constant bin width and relative bounds; d<sub>ii</sub>: constant number of bins and relative bounds; d<sub>iii</sub>: constant number of bins and absolute bounds. The impact of the volume of the region was also tested within the WM. First, the mean Hellinger distance between patient-based intensity distributions decreased by a factor greater than 10 in WM and greater than 2.5 in gray...
Source: Physics in Medicine and Biology - Category: Physics Authors: Tags: Phys Med Biol Source Type: research