Latin America & the Caribbean Edging Towards Eliminating Tuberculosis

Tuberculosis, world's top infectious killer. Credit: UNBy Grace VirtueWASHINGTON DC, Mar 16 2018 (IPS)Known as El Libertador throughout the Latin America and Caribbean (LAC) region, Simón Bolívar was central to the battle for independence from Spanish rule in Venezuela, Bolivia, Colombia, Ecuador, and Peru. A less known fact is that Bolívar, the son of a wealthy Venezuelan creole family, died from tuberculosis (TB) on December 17, 1880, at age 47. His compatriot, renowned impressionist Cristobal Rojas, painted La Miseria in 1886, depicting the social conditions of the day that gave rise to TB. He died from the disease in 1890 at age 33.Tuberculosis is an ancient disease. Results from a 2014 DNA study of remains in southern Peru suggest that human TB was present 6,000 years ago. This chronic familiarity of the disease no doubt makes it more difficult to generate the attention required to eradicate it from the human experience.Observed as World TB Day each year, March 24 is the annual opportunity for advocates and interest groups to build public awareness about the disease, which killed 1.7 million people in 2017 and sickened more than 10 million. The date marks the anniversary of the announcement in 1882 by Robert Koch, a German physician and microbiologist, that he had discovered the cause of TB: the tubercle bacillus.Koch’s work was seminal in the treatment of TB—also known as the white plague—which was devastating populations in Europe...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Development & Aid Economy & Trade Featured Headlines Health Latin America & the Caribbean Population Poverty & SDGs TerraViva United Nations Trade & Investment Source Type: news

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By Anis Chowdhury and Jomo Kwame SundaramSYDNEY and KUALA LUMPUR, May 26 2020 (IPS) With well over five million Covid-19 infections worldwide, and deaths exceeding 340,000, the race for an effective vaccine has accelerated since the SARS-Cov-2 virus was first identified as the culprit. Expecting to score politically from being ‘first’ to have a vaccine, US President Trump’s Operation Warp Speed promises to get 300 million doses to Americans by January, after the November polls, following several failed attempts to monopolize vaccines being developed by European companies. Anis Chowdhury More than 115 vac...
Source: IPS Inter Press Service - Health - Category: International Medicine & Public Health Authors: Tags: Aid Economy & Trade Featured Global Headlines Health Humanitarian Emergencies TerraViva United Nations Jomo Kwame Sundaram & Anis Chowdhury Source Type: news
ov VV Abstract Tuberculosis (TB) disease remains to be an alarming infection worldwide with nearly 1.6 million deaths per year ranking above HIV/AIDS. Although Mycobacterium tuberculosis (Mtb), which causes TB, was identified more than 130 years ago, nowadays only old vaccine (Bacillus Calmette-Guérin vaccine) and classical toxic drugs that are losing its effectiveness are available in clinic practice. Despite enormous efforts in drug research on TB treatment including vaccines and diagnostics investigations, this old contagious, infectious disease is still a major public health problem. The goal of elimina...
Source: European Journal of Pharmaceutical Sciences - Category: Drugs & Pharmacology Authors: Tags: Eur J Pharm Sci Source Type: research
The United Nation High Commission for Refugees (UNHCR) estimates that there are approximately 25.9 million refugees worldwide [1]. The adverse living conditions, poor nutrition, low health literacy as well as physical and mental stress encountered by refugees increases the risk of these underprivileged individuals acquiring communicable diseases such as hepatitis, parasitic disease, and respiratory infections including tuberculosis (TB) [2]. As such, rapid diagnosis and appropriate treatment among all refugees for active TB as a strategy to control TB should be a global priority to achieve the United Nations Sustainable De...
Source: European Respiratory Journal - Category: Respiratory Medicine Authors: Tags: Original Articles: Correspondence Source Type: research
In this study we show for the first time the interaction between MTB Beijing-genotype strains and BCG-vaccinated hosts. Using a well-controlled murine model of progressive pulmonary tuberculosis, we vaccinated BALB/c mice with two different sub-strains of BCG (BCG-Phipps and BCG-Vietnam). Following vaccination, the mice were infected with either one of three selected MTB strains. Strains were selected based on lineage, and included two Beijing-family clinical isolates (strains 46 and 48) and a well-characterized laboratory strain (H37Rv). Two months after infection, mice were euthanized and the bacteria extracted from thei...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
t-Schiltz Michel Rivière To date, Mycobacterium tuberculosis (Mtb) remains the world’s greatest infectious killer. The rise of multidrug-resistant strains stresses the need to identify new therapeutic targets to fight the epidemic. We previously demonstrated that bacterial protein-O-mannosylation is crucial for Mtb infectiousness, renewing the interest of the bacterial-secreted mannoproteins as potential drug-targetable virulence factors. The difficulty of inventorying the mannoprotein repertoire expressed by Mtb led us to design a stringent multi-step workflow for the reliable identification of glyc...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
If used with adequate testing, isolation and social distancing, tracing could be key to reducing the spread of Covid-19Coronavirus – latest updatesSee all our coronavirus coverageAs quarantine measures are slowly lifted in the UK, the virus will continue to spread unless the government puts in place a strategy to curb the rate of infection.Contact tracing, a practice long used in public health to control infectious diseases, will be crucial to driving down the rate of infection, or R, and minimising further cases of coronavirus.Epidemiologists have been using traditional contact tracing for years to control sexually ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Coronavirus outbreak Infectious diseases Science Epidemics UK news Source Type: news
Conclusion: The changing epidemic of ocular disease in HIV-infected patients warrants close monitoring and identification of interventions that can help reduce the imminent burden of disease. PMID: 32396027 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
By Jane Amago; Irene Mirembe, Knowledge management manager, IntraHealth International In Uganda, communities have years of experience with epidemics like Ebola and HIV, and can draw on their rich shared history to support their families and communities in this crisis. Patrick ’s service to his community is a symbol of Ugandan resilience. Photo by Irene Mirembe for IntraHealth International.May 13, 2020Wiasana Patrick Were is a case manager at Busolwe Hospital in Butaleja district, Uganda, where new lockdowns due to COVID-19 have resulted in travel restrictions. That me...
Source: IntraHealth International - Category: International Medicine & Public Health Authors: Tags: COVID-19 Source Type: news
Individuals with non-communicable diseases (NCDs) are susceptible to communicable diseases (CDs) as the current COVID-19 pandemic as well as previous infections with Middle Eastern respiratory syndrome (MERS), severe acute respiratory syndrome (SARS) and tuberculosis illustrate. While CD epidemics are “fast and furious,” the pandemics of NCDs, such as diabetes, obesity, and hypertension are silent, “slow-motion” killers with far greater tolls on mortality, disability, and costs [1]. Furthermore, the co-occurrence of diabetes with CDs predicts greater severity, and death, as we see with CO VID-19 [2].
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Tags: Commentary Source Type: research
[MSF] As the number of people with COVID-19 grows daily, Eswatini is now battling yet another health crisis on top of existing epidemics of HIV and tuberculosis (TB)
Source: AllAfrica News: HIV-Aids and STDs - Category: Infectious Diseases Source Type: news
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