One year in review 2017: spondyloarthritis.

One year in review 2017: spondyloarthritis. Clin Exp Rheumatol. 2018 Jan-Feb;36(1):1-14 Authors: Terenzi R, Monti S, Tesei G, Carli L Abstract The term spondyloarthritis (SpA) represents a condition characterised by a broad spectrum of clinical manifestations, laboratory abnormalities and imaging features; in particular, SpA is an inflammatory condition in which both peripheral and axial joints might be affected. The majority of people with this disease have either psoriatic arthritis or axial spondyloarthritis, which includes ankylosing spondylitis. Less common subgroups are enteropathic SpA, which is associated with inflammatory bowel diseases (Crohn's disease and ulcerative colitis), reactive arthritis, which can occur in people following gastrointestinal or genitourinary infections and undifferentiated SpA, that does not meet the diagnostic criteria of the other subgroups at onset, but that may evolve to do so later. Very interestingly, much of the emerging data show how SpA, during its course, tends to associate with the development of some comorbidities; in particular, with cardiovascular diseases, diabetes mellitus, osteoporosis and depressive disorders. Healthcare professionals in non-specialist settings do not always recognise the signs and symptoms of SpA, particularly spinal symptoms, which may be mistakenly attributed to other causes of low back pain, thus leading to significant delays in diagnosis and treatment of the disease itself and of i...
Source: Clinical and Experimental Rheumatology - Category: Rheumatology Tags: Clin Exp Rheumatol Source Type: research

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Publication date: Available online 18 July 2018Source: Journal of ColoproctologyAuthor(s): Alvaro Ariel Gomez, Thiago Franchi Nunes, Carlos Henrique Marques dos Santos, Denise Maria Rissato, Tiago Kojun Tibana, Isa Felix Adôrno, Doroty Mesquita DouradoAbstractContextThere is an increasing interest in the standardization of the evaluation of imaging exams, especially enterography in Crohn’s disease.ObjectiveTo compare the quality of the conventional report with the structured report in computed tomography enterography in Crohn’s disease.MethodNine CT enterographies of patients with Crohn’s disease wi...
Source: Journal of Coloproctology - Category: Gastroenterology Source Type: research
Publication date: Available online 29 December 2017Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Hiroshi Yamazaki, Takatsugu Suzuki, Yuya Denda, Yasuhiro Nakanishi, Masahiro Uchibori, Rena Kojima, Yusuke Kondo
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 26 April 2017Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral RadiologyAuthor(s): Mina D. Fahmy, Anish Gupta, Amrou Abdelkader, Theodore MacKinney, Steven Sewall
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - Category: ENT & OMF Source Type: research
Publication date: Available online 18 July 2018Source: Diabetes &Metabolic Syndrome: Clinical Research &ReviewsAuthor(s): Farbod Ebadifard Azar, Mahnaz Solhi, Fatemeh Darabi, Alireza Rohban, Mitra Abolfathi, Nazila NejhaddadgarAbstractAimsDiabetes mellitus is a chronic and progressive disease which requires ongoing medical care as well as patient’s self-care skills to prevent acute complications. The purpose of this study is to determine the effect of the PRECEDE-PROCEED model combined with self-management theory on self-care behaviors in type 2 diabetic patients.MethodsIn this semi-experimental study, 86 typ...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - Category: Endocrinology Source Type: research
In patients with type 2 diabetes not at glycemic goal, adding a sulfonylurea to metformin appears to be much safer than switching.Medscape Medical News
Source: Medscape Diabetes Headlines - Category: Endocrinology Tags: Diabetes & Endocrinology News Source Type: news
Publication date: Available online 18 July 2018Source: Pharmacological ResearchAuthor(s): Nathan Griffin, Sam Faulkner, Phillip Jobling, Hubert HondermarckAbstractNerve outgrowth in the tumor microenvironment (tumor neurogenesis) has recently been shown to be essential for cancer progression and the concept of nerve dependence is emerging in oncology. Neurotrophins such as nerve growth factor (NGF) have long been identified as drivers of neurogenesis during development and regeneration, but intriguingly they were also known to be expressed in human tumors where they can stimulate cancer cell growth. Recent findings have un...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 17 July 2018Source: Pharmacological ResearchAuthor(s): B. Lavoie, J.A. Roberts, M.M. Haag, S.N. Spohn, K.G. Margolis, K.A. Sharkey, J.B. Lian, G.M. MaweABSTRACTOsteoporosis and bone fractures occur at higher frequency in patients with inflammatory bowel disease (IBD), and decreased bone mass is observed in animal models of colitis. Another consistent feature of colitis is increased serotonin (5-HT) availability in the intestinal mucosa. Since gut-derived 5-HT can decrease bone mass, via activation of 5-HT1B receptors on pre-osteoblasts, we tested the hypothesis that 5-HT contributes to bo...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 17 July 2018Source: Pharmacological ResearchAuthor(s): Mattia Albiero, Gian Paolo FadiniAbstractDiabetes is a chronic metabolic disease characterized by hyperglycemia and several associated biochemical abnormalities. Diabetes leads to multiorgan complications that collectively reduce life expectancy. Hematopoietic stem cells (HSCs) are nested within bone marrow (BM) niches whence they can be mobilized to the peripheral circulation. Clinically, this is done for HSC collection and autologous or allogenic transplantation. A great amount of data from basic and clinical studies support that di...
Source: Pharmacological Research - Category: Drugs & Pharmacology Source Type: research
Publication date: Available online 18 July 2018Source: Journal of Pharmacological and Toxicological MethodsAuthor(s): Murilo S. de Abreu, Ashton J. Friend, Konstantin A. Demin, Tamara G. Amstislavskaya, Wandong Bao, Allan V. KalueffAbstractDepression is a wide-spread, debilitating psychiatric disorder. Mainly rodent-based, experimental animal models of depression are extensively used to probe the pathogenesis of this disorder. Here, we emphasize the need for innovative approaches to studying depression, and call for a wider use of novel model organisms, such as the zebrafish (Danio rerio). Highly homologous to humans and r...
Source: Journal of Pharmacological and Toxicological Methods - Category: Drugs & Pharmacology Source Type: research
ConclusionsThis study explored the antidepressant potential of A. wiedemanniana. Using bioassay-guided fractionation and isolation techniques, tatridin A and tanachin (1-epi-tatridin B) were determined as the main active components of the flowers. Further antidepressant mechanistic studies should be conducted for exploring the activity of these compounds against depression. This study can be an important step in the discovery of newer antidepressants.Graphical abstract
Source: Journal of Ethnopharmacology - Category: Drugs & Pharmacology Source Type: research
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