Pyroptosis: an inflammatory link between NAFLD and NASH with potential therapeutic implications

Non-alcoholic fatty liver disease (NAFLD) represents a major health problem Worldwide due to its high and rising prevalence, association with cardiovascular diseases, and risk for developing cirrhosis and hepatocellular carcinoma (HCC). NAFLD is classified in different degrees, from simple steatosis (overall 20-30% prevalence), which is considered “benign”, to steatohepatitis (NASH: 2-5% prevalence) and fibrosis.[1,2] The major risk factors of NAFLD include metabolic syndrome (i.e. obesity, diabetes, hypercholesterolemia and hypertriglyceridemia), sedentary lifestyle, genetic predispositions (e.g.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Source Type: research