Insulin acutely potentiates M3 muscarinic receptor function in rat and human airway smooth muscle

Conclusions: In addition to increasing acetylcholine release via loss of M2 function, insulin may also contribute to airway hyperreactivity in obesity induced asthma by increasing M3 receptor mediated contraction of airway smooth muscle.Grants: R01HL131525, R01HL113023, R01AR061567, R01HL124165, R01ES017592, Health Effects Institute.

Source: European Respiratory Journal - December 6, 2017 Category: Respiratory Medicine Authors: Nie, z., Jacoby, D., Fryer, A. Tags: Airway Cell Biology and Immunopathology Source Type: research