Description of Cardiovascular Event Rates in Patients Initiating Chronic Opioid Therapy for Noncancer Pain in Observational Cohort Studies in the US, UK, and Germany.

CONCLUSIONS: CV risk for new opioid users with ≥6 months of therapy was increased in patients with established CV disease compared with those without established CV disease, and the risk for specific outcomes differed by country. Assessment of CV safety events of new therapies introduced to chronic opioid users should consider sample size and population heterogeneity in the design of an observational study.
PMID: 25033926 [PubMed - as supplied by publisher]

Source: Advances in Therapy - July 18, 2014 Category: Drugs & Pharmacology Authors: LoCasale R, Kern DM, Chevalier P, Zhou S, Chavoshi S, Sostek M Tags: Adv Ther Source Type: research