Alternative medicine for cancer: Greater scrutiny is needed

As the calendar turns to early October, I’m reminded that this is the 6th anniversary of Steve Jobs’ death. At the time of his death, I was a medical student and my wife had just completed six months of chemotherapy. I was surprised to learn that Jobs had died from complications of cancer and shocked to discover that he had initially refused conventional cancer treatment in favor of alternative medicines. At first, I found it difficult to understand how someone with the intellectual and financial resources of Steve Jobs could make such a decision — but I was quickly reminded of the massive amounts of misinformation that I encountered online while researching my wife’s cancer diagnosis. Rather than question Jobs’ intelligence, I wanted to explore how he had been deceived. Following his death, news reports suggested that the qualities that made him successful in resurrecting businesses from the ashes, namely confidence, passion, and fearlessness, may have contributed to his early death. He died from complications of pancreatic neuroendocrine cancer, a rare albeit curable disease. Diagnosed in 2003, Jobs initially defied doctors’ recommendations to undergo surgery. He distrusted Western medicine, and believed that there was a better, more natural way to cure cancer.  Over the next several months, he relied solely on a vegan diet, acupuncture, and other natural herbal remedies. He eventually agreed to undergo surgery, but unfortunately, Jo...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Physician Endocrinology Oncology/Hematology Source Type: blogs

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Authors: Kim MS, Lee K, Ku JM, Choi YJ, Mok K, Kim D, Cheon C, Ko SG Abstract Pancreatic cancer has a poor prognosis with a five-year survival rate of less than 10%. Moreover, chemotherapy is mostly rendered ineffective owing to chemotherapy resistance and cytotoxicity. Therefore, the development of effective therapeutic strategies and novel drugs against pancreatic cancer is an urgent need. Cucurbitacin D (CuD), a plant steroid derived from Trichosanthes kirilowii, is an anticancer agent effective against various cancer cell lines. However, the anticancer activity and molecular mechanism of CuD in pancreatic cance...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
ConclusionFollow-up cachexia had an early onset, but was not a prognostic factor for overall survival in patients with PDAC. Some adverse events tended to be more frequent in patients with follow-up cachexia than in those without follow-up cachexia.
Source: Supportive Care in Cancer - Category: Cancer & Oncology Source Type: research
Conclusions: Assessment of JAK2 protein expression may be a promising method to predict prognosis in patients with resectable PDAC. PMID: 33029256 [PubMed - in process]
Source: Disease Markers - Category: Laboratory Medicine Tags: Dis Markers Source Type: research
Conditions:   Pancreatic Cancer;   Chemotherapy Effect Interventions:   Drug: raltitrexed for injection;   Drug: nab-paclitaxel Sponsor:   Fudan University Recruiting
Source: - Category: Research Source Type: clinical trials
Authors: Hwang JS, Joo HD, Song TJ Abstract Surgical resection is considered the only treatment option for pancreatic cancer and other pancreatic neoplasms with malignant potential, such as neuroendocrine tumors, mucinous cystic neoplasms, and intraductal papillary mucinous neoplasms. However, only 10%-20% of all patients with pancreatic cancer present with resectable forms of the disease as the symptoms are rarely manifested during the early stages, and the disease tends to progress rapidly. Furthermore, pancreatic surgery is associated with high rates of morbidity and mortality. The development of linear-array en...
Source: Clinical Endoscopy - Category: Gastroenterology Tags: Clin Endosc Source Type: research
Pancreatic cancer (PC) is one of the most common cancers and the leading cause of cancer-related death worldwide. Exploring novel predictive biomarkers for PC patients ’ prognosis is in urgent need.
Source: Cancer Cell International - Category: Cancer & Oncology Authors: Tags: Primary research Source Type: research
ConclusionsThis study demonstrated the feasibility of total laparoscopic pancreaticoduodenectomy combined with vascular resection and artificial vascular graft reconstruction in properly selected cases of pancreatic cancer with vein involvement after neoadjuvant chemotherapy. It is worth noting that skilled laparoscopic technicians and effective teamwork are necessities for safe completion of the procedure.
Source: Journal of Gastrointestinal Surgery - Category: Surgery Source Type: research
We present a case of LGI1 encephalitis only partially responsive to immunotherapy with eventual complete resolution after resection of a squamous cell lung carcinoma.
Source: Neurology Neuroimmunology and Neuroinflammation - Category: Neurology Authors: Tags: Autoimmune diseases, Dystonia, Paraneoplastic syndrome, All Epilepsy/Seizures Clinical/Scientific Notes Source Type: research
This study analyzed QoL data from a prospective multicenter patient-reported outcome registry in patients with pancreatic or periampullary carcinoma registered in the nationwide Netherlands Cancer Registry (2015-2018). Baseline and delta QoL, between baseline and 3-month follow-up, were assessed with the Happiness, EORTC Quality of Life Questionnaire-Core 30 (QLQ-C30), and QLQ-PAN26 questionnaires. The relationship between QoL and survival was assessed using Cox regression models, and additional prognostic value of separate items was assessed using Nagelkerke R2 (explained variance). RESULTS: For the baseline and delta...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research
This study describes the antiproliferative and antimigration effects of beauvericin from a culture broth of Isaria sp. in human pancreatic cancer cells (PANC-1). Activity-guided fractionation of the EtOAc extract of cultured broth of Isaria sp. RD055140 afforded beauvericin (1), a new isariotin derivative, 7-O-methylisariotin C (2), together with the known isariotin analogs, TK-57-164A (3) and B (4). As a result of the measurement of the cell viability, 1 inhibited cell growth (IC50 = 4.8 µM) of PANC-1 cells. Furthermore, 1 was found to inhibit the migration activity of PANC-1 cells by upregulating the expression...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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