Copper ATSM/PTSM Mechanism in Cells without Mitochondria

Conclusion: The preliminary data suggests that the reduced cell environment is not the primary factor driving dissociation of the complex; it is rather endogenous copper demand driven by complex physiological processes including oxidative stress, and cell growth. Further studies are planned to investigate the primary mechanism by which Cu-ATSM releases the tracer to cells, providing an imaging signal reflective of cellular pathology in multiple disease states. Research Support: 2 P01 CA042045
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Radiopharmacy Posters Source Type: research