Stroke risk in treatment of type 2 diabetes in China: a 7 year retrospective cohort study

Publication date: November 2016 Source:The Lancet Diabetes & Endocrinology, Volume 4, Supplement 1 Author(s): Rui Liu, Qing Wang, Vivian Szeto, Andrew Barszczyk, Tianru Jin, Edoardo Mannucci, Hong-Shuo Sun, Zhong-Ping Feng Background Diabetes and stroke are leading causes of death and disability, and major public health concerns in China, which accounts for 25% of patients with diabetes worldwide. Type 2 diabetes is an independent risk factor for cerebral ischaemia and accounts for about 20% of stroke cases. We previously showed that KATP channel activation provides neuroprotection against cerebral ischaemia and that sulfonylureas blocking these channels increase the stroke risk in patients with type 2 diabetes. We aimed to further determine whether different classes of antidiabetic drugs increase the risk of stroke in Chinese patients with type 2 diabetes. Methods In this retrospective cohort study, we used data from medical records (Jan 1, 2008, to Dec 30, 2015) of the Endocrinology Division of the Third Affiliated Hospital of Jilin University, Jilin, China. Patients aged 32–80 years with type 2 diabetes whose blood glucose control treatment included sulfonylureas, metformin, insulin, or restricted diet were eligible for inclusion. All patients also received education on diet, exercise, blood glucose monitoring, and other aspects of diabetes management. We used χ2 test was to determine significance (p<0·05) between two sets of categorical data ...
Source: The Lancet Diabetes and Endocrinology - Category: Endocrinology Source Type: research