EXTH-52. ASSESSMENT OF TRYPTOPHAN UPTAKE AND KINETICS USING 1-(2-[F-18]FLUOROETHYL)-TRYPTOPHAN AND {alpha}-[C-11]-METHYL-L-TRYPTOPHAN PET IMAGING IN MICE IMPLANTED WITH PATIENT-DERIVED BRAIN TUMOR XENOGRAFTS

CONCLUSIONS:[18F]FETrp tumoral uptake, biodistribution and radiation dosimetry data provide strong preclinical evidence that this new radiotracer is worth further studies that may lead to a new, broadly-applicable molecular imaging tool to study abnormal tryptophan metabolism in human tumors.

Source: Neuro-Oncology - November 6, 2016 Category: Cancer & Oncology Authors: Michelhaugh, S. K., Muzik, O., Guastella, A. R., Klinger, N. V., Polin, L. A., Cai, H., Xin, Y., Mangner, T. J., Juhasz, C., Mittal, S. Tags: EXPERIMENTAL THERAPEUTICS - PRECLINICAL STUDIES (NON-IMMUNOLOGICAL) Source Type: research