Ecology and Evolution of Infectious Diseases

Funding Opportunity ID: 287690 Opportunity Number: 16-592 Opportunity Title: Ecology and Evolution of Infectious DiseasesOpportunity Category: DiscretionaryOpportunity Category Explanation: Funding Instrument Type: GrantCategory of Funding Activity: Science and Technology and other Research and DevelopmentCategory Explanation: CFDA Number(s): 10.31047.07447.07593.85693.85993.989Eligible Applicants: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled "Additional Information on Eligibility"Additional Information on Eligibility: Agency Code: NSFAgency Name: National Science FoundationPosted Date: Aug 19, 2016Close Date: Nov 16, 2016Last Updated Date: Aug 19, 2016Award Ceiling: $2,500,000Award Floor: $1,000,000Estimated Total Program Funding: $13,500,000Expected Number of Awards: Description: The Ecology and Evolution of Infectious Diseases program supports research on the ecological, evolutionary, and socio-ecological principles and processes that influence the transmission dynamics of infectious diseases. The central theme of submitted projects must be quantitative or computational understanding of pathogen transmission dynamics. The intent is discovery of principles of infectious disease transmission and testing mathematical or computational models that elucidate infectious disease systems. Projects should be broad, interdisciplinary efforts that go beyond the scope of typical studies. They should foc...
Source: Grants.gov - Category: Research Tags: Science and Technology and other Research and Development Source Type: funding

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This study aimed to develop a rapid, sensitive and reliable duplex real-time PCR assay for the specific detection and differentiation of these Anaplasma species.We designed primers and probes against the conserved regions of A. capra groEL and A. phagocytophilum 16S rRNA genes. A range of PCR-related parameters were evaluated such as the dosage of primers and probes, and annealing temperature. The specificity, sensitivity and repeatability of this assay were evaluated. Assay performance was further evaluated using samples collected from 124 goats in four regions of Henan, China. This set of samples was also tested using co...
Source: Molecular and Cellular Probes - Category: Molecular Biology Source Type: research
AbstractA survey was completed to determine water use by small-scale dairy farms in Mexicali Valley of Mexico and to associate it with dairy production parameters. Mexicali Valley surrounds the capital city of the state Baja California, Mexicali. Sixty-one smallholders were interviewed in person in this rural area of northwestern Mexico. On average, small dairy holders had more than 20 years of experience and were ~ 55 years of age; people working on their farms are especially relatives. A low percentage was literate (20%), and they belong to a local dairy association. Milk yield/cow/year does not reach 4000 kg of milk and...
Source: Tropical Animal Health and Production - Category: Veterinary Research Source Type: research
Lyme disease is caused by a tick-borne bacterium Borrelia sp. This zoonotic infection is common in the Northern Hemisphere, e.g., Europe. Clinical presentation may involve multisystem symptoms and depends on the stage of the disease. The involvement of nervous system in Lyme disease is commonly referred to as neuroborreliosis. Neuroborreliosis may involve meningitis, mononeuritis multiplex, or cranial neuritis including the inflammation of vestibulocochlear nerve. In the late or chronic stage of Lyme disease, vestibular involvement may be the sole presentation, although such cases are rare. Our study was designed to presen...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
Vector-Borne and Zoonotic Diseases, Ahead of Print.
Source: Vector-Borne and Zoonotic Diseases - Category: Infectious Diseases Authors: Source Type: research
In this study, we discovered that the capsid protein antagonizes IFN induction. Mechanistically, the capsid protein blocked the phosphorylation of IFN regulatory factor 3 (IRF3) via interaction with the multiprotein complex consisting of mitochondrial antiviral-signaling protein (MAVS), TANK-binding kinase 1 (TBK1), and IRF3. The N-terminal domain of the capsid protein was found to be responsible for the inhibition of IRF3 activation. Further study showed that the arginine-rich-motif in the N-terminal domain is indispensable for the inhibition as mutations of any of the arginine residues abolished the blockage of IRF3 phos...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research
This study presents the first evidence that the transcriptional regulator VjbR has important function in B. canis. In addition, according to its reduced virulence and the protective immunity it induces in mice, it can be a potential live attenuated vaccine against B. canis.
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 8 November 2019Source: Microbial PathogenesisAuthor(s): Maryam Dadar, Youcef Shahali, Yadolah FakhriAbstractBrucella spp. Is Gram-negative coccobacilli that may grow in different media and environmental conditions for extended periods of time. The survivals of these bacteria in the environment have an important impact on the epidemiology of brucellosis worldwide. The effect of climate on the incidence of certain zoonotic infectious diseases, (recently referred to as climate-sensitive zoonosis) is now well established. The aim of this study was to evaluate the relation between the incidenc...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
In this study, sixty significant differentially expressed genes were screened between susceptible and resistant sheep macrophages by transcriptome RNA-seq. Eight significantly enriched GO terms and six canonical pathways were involved by GO and KEGG enrichment analysis. Furthermore, the function of HMOX1, SLPI and SPP1 was verified by siRNA, which the knockdown of HMOX1 and SLPI increased remarkably the clearance of S. typhimurium, but SPP1 had little effect on the clearance of S. Typhimurium within sheep macrophages. Altogether, these results suggest that many genes of macrophages were reprogrammed via S. Typhimurium infe...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: Available online 9 November 2019Source: Ticks and Tick-borne DiseasesAuthor(s): Khushal Khan Kasi, Miriam Andrada Sas, Carola Sauter-Louis, Felicitas von Arnim, Jörn Martin Gethmann, Ansgar Schulz, Kerstin Wernike, Martin H. Groschup, Franz J. ConrathsAbstractCrimean-Congo haemorrhagic fever (CCHF) is a tick-borne zoonotic disease caused by the arbovirus Crimean-Congo haemorrhagic fever virus (CCHFV). Livestock serve as a transient reservoir for CCHFV, but do not show clinical signs. In this cross-sectional study, sheep and goats in Balochistan, Pakistan, were examined to determine the CCHFV seroprev...
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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