Decline in dog sperm quality 'could be a concern for humans'

Conclusion This animal study aimed to assess changes in sperm quality in dogs over time. Within this, the researchers looked at whether chemicals in the environment may play a role in the observed trends. The study reported a decline in sperm quality in canines over the 26-year study period, as well as an increase in the incidence of cryptorchidism in the dogs' male offspring during an overlapping timeframe. The media interest in this study revolves around the idea that the decline in dogs' sperm quality can be linked to the decline in fertility also observed in men. Further research would need to be conducted in humans to investigate the reasons behind the suspected decline. The researchers also detected the chemicals PCB congeners, PBDE congeners and DEHP in the canine adult testis and semen. But although these findings are interesting, the study did not aim to – and is not able to – confirm a link between environmental chemicals and sperm quality. Professor Allan Pacey, Professor of Andrology at the University of Sheffield, said: "This is an interesting study which suggests that the sperm quality in a population of dogs enrolled in a breeding programme in the UK may have declined over a 26-year period, in a manner which mimics what others have claimed may have happened in the human male over the last century. "Whilst I am not a strong supporter of the idea that sperm quality in humans has declined significantly – we have changed too much ab...
Source: NHS News Feed - Category: Consumer Health News Tags: Pregnancy/child Lifestyle/exercise Source Type: news

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AbstractAutophagy is crucial for the removal of dysfunctional organelles and protein aggregates and for maintaining stem cell homeostasis, which includes self-renewal, cell differentiation and somatic reprogramming. Loss of self-renewal capacity and pluripotency is a major obstacle to stem cell-based therapies. It has been reported that autophagy regulates stem cells under biological stimuli, starvation, hypoxia, generation of reactive oxygen species (ROS) and cellular senescence. On the one hand, autophagy is shown to play roles in self-renewal by co-function with the ubiquitin-proteasome system (UPS) to promote pluripote...
Source: Cell and Tissue Research - Category: Cytology Source Type: research
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Source: Cell - Category: Cytology Source Type: research
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Source: Cell - Category: Cytology Source Type: research
Publication date: 18 October 2018Source: Cell, Volume 175, Issue 3Author(s): David A. Quigley, Ha X. Dang, Shuang G. Zhao, Paul Lloyd, Rahul Aggarwal, Joshi J. Alumkal, Adam Foye, Vishal Kothari, Marc D. Perry, Adina M. Bailey, Denise Playdle, Travis J. Barnard, Li Zhang, Jin Zhang, Jack F. Youngren, Marcin P. Cieslik, Abhijit Parolia, Tomasz M. Beer, George Thomas, Kim N. Chi
Source: Cell - Category: Cytology Source Type: research
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Source: Cell - Category: Cytology Source Type: research
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Source: Cell - Category: Cytology Source Type: research
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Source: Cell - Category: Cytology Source Type: research
Publication date: Available online 20 October 2018Source: Journal of Clinical NeuroscienceAuthor(s): Aaron E. Miller, Xianhao Xu, Richard Macdonell, Steve Vucic, Philippe Truffinet, Myriam Benamor, Karthinathan Thangavelu, Mark S. FreedmanAbstractIn the phase 3 TOWER (NCT00751881) study, teriflunomide 14 mg significantly reduced annualized relapse rate (ARR) and risk of 12-week confirmed disability worsening (12-w CDW) vs placebo in patients with relapsing forms of MS (RMS). The TOWER population included an appreciable proportion of Asian patients. Reductions in ARR and 12-w CDW associated with teriflunomide 14 mg were...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
DISCUSSION: The routine PE of FH specimens after arthroplasty for femoral neck fractures is not warranted and uneconomic. Sending the FH for PE, only when clinically indicated, rather than routine, will result in notable savings for the healthcare system. LEVEL OF EVIDENCE: Level IV. PMID: 30334845 [PubMed - as supplied by publisher]
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
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Source: Brain Injury - Category: Neurology Tags: Brain Inj Source Type: research
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