Decline in dog sperm quality 'could be a concern for humans'

Conclusion This animal study aimed to assess changes in sperm quality in dogs over time. Within this, the researchers looked at whether chemicals in the environment may play a role in the observed trends. The study reported a decline in sperm quality in canines over the 26-year study period, as well as an increase in the incidence of cryptorchidism in the dogs' male offspring during an overlapping timeframe. The media interest in this study revolves around the idea that the decline in dogs' sperm quality can be linked to the decline in fertility also observed in men. Further research would need to be conducted in humans to investigate the reasons behind the suspected decline. The researchers also detected the chemicals PCB congeners, PBDE congeners and DEHP in the canine adult testis and semen. But although these findings are interesting, the study did not aim to – and is not able to – confirm a link between environmental chemicals and sperm quality. Professor Allan Pacey, Professor of Andrology at the University of Sheffield, said: "This is an interesting study which suggests that the sperm quality in a population of dogs enrolled in a breeding programme in the UK may have declined over a 26-year period, in a manner which mimics what others have claimed may have happened in the human male over the last century. "Whilst I am not a strong supporter of the idea that sperm quality in humans has declined significantly – we have changed too much ab...
Source: NHS News Feed - Category: Consumer Health News Tags: Pregnancy/child Lifestyle/exercise Source Type: news

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In this study, MHC-1 and PDL-1 score in primary and metastatic tumor cells was evaluated in 43 gastric cancer patients with lymph node metastasis. According to our results, the primary tumor PDL-1 score was correlated with the number of metastatic lymph nodes (r = 0.258; p = 0.024) and primary tumor size (r = 0.341; p = 0.045). A similar correlation was found between the primary tumor PDL-1 score and the metastatic tumor PDL-1 score (r = 0.213; p = 0.015). In our study, MHC-1 was found to be higher in primary tumors than metastatic tumors, although not statistically significant (p = 0.054). The results of our study showed ...
Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
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Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
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Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
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Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
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Source: Biomolecular Detection and Quantification - Category: Molecular Biology Source Type: research
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Source: Life Sciences - Category: Biology Source Type: research
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