Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine–induced apoptosis in neuroblastoma cells

This study provides new insights into understanding the molecular and cellular mechanisms involved in PBOX-induced cell death in neuroblastoma and further supports their future use as novel anti-cancer agents for the treatment of neuroblastoma.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research

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Authors: Koyuncu Özyurt Ö, Özhak B, Öğünç D, Yıldız E, Çolak D, Günseren F, Öngüt G Abstract Infections with multidrug resistant gram-negative bacteria is a growing problem especially in health care settings. Colistin is one of the last resort antibiotics for such infections in which treatment options are limited. Increasing resistance to colistin is a global problem. Clinical and Laboratory Standards Institute (CLSI) and the European Committee on Antimicrobial Susceptibility Testing (EUCAST) study groups have recommended the ISO-standard broth microdilution ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Authors: Bozok T, Kayar B, Yakıcı G, Eker E, Marzi M, Karslı F, Köksal F Abstract Tuberculosis (TB) is a chronic, granulomatous and necrotizing disease caused by microorganisms belonging to the Mycobacterium tuberculosis complex group. In 2017, 6.4 million new TB cases have been reported according to the World Health Organization 2018 Global Tuberculosis Report. TB remains among the major health problems of our time due to the increasing drug resistance problem and the difficulties in definitive diagnosis in recent years. It is stated by clinicians that intensive use of quinolone group drugs with oral form ...
Source: Mikrobiyoloji Bulteni - Category: Microbiology Tags: Mikrobiyol Bul Source Type: research
Journal Name: Journal of Perinatal Medicine Issue: Ahead of print
Source: Journal of Perinatal Medicine - Category: Perinatology & Neonatology Source Type: research
CONCLUSIONS The effect of PL on the SDF-1-CXCR4/CXCR7 axis has become an attractive target for inhibiting angiogenesis in hepatoma cells. Our results provide more evidence for the clinical application of PL as part of traditional Chinese medicine in modern cancer treatment. PMID: 31415486 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
In conclusion, this study recognized linc00460 as a new oncogenic lncRNA in OS and suggests that the linc00460/miR-1224-5p/FADS1 axis might be a potential therapeutic target for OS.
Source: Life Sciences - Category: Biology Source Type: research
Publication date: Available online 17 August 2019Source: Journal of Theoretical BiologyAuthor(s): M. Chowkwale, G.J. Mahler, P. Huang, B.T. MurrayAbstractEndothelial to mesenchymal transformation (EndMT) is a process in which endothelial cells gain a mesenchymal-like phenotype in response to mechanobiological signals that results in the remodeling or repair of underlying tissue. While initially associated with embryonic development, this process has since been shown to occur in adult tissue remodeling including wound healing, fibrosis, and cancer. In an attempt to understand the role of EndMT in cancer progression and meta...
Source: Journal of Theoretical Biology - Category: Biology Source Type: research
Publication date: 15 November 2019Source: Carbohydrate Polymers, Volume 224Author(s): Mengyao Zhao, Liming Gu, Yun Li, Shumin Chen, Jiangshan You, Liqiang Fan, Yudong Wang, Liming ZhaoAbstractGynecological cancers are the most commonly diagnosed forms of cancer among the female population. Chitooligosaccharides (COS)—hydrolysis products from chitosan—display high bioavailability, high water solubility, and low molecular weight properties. Here, we investigated the influence of COS on 11 gynecological tumor cell types, and subsequently elucidated molecular mechanisms through which the observed inhibition occurre...
Source: Carbohydrate Polymers - Category: Biomedical Science Source Type: research
Publication date: Available online 17 August 2019Source: PolymerAuthor(s): Sakineh Hajebi, Amin Abdollahi, Hossein Roghani-Mamaqani, Mehdi Salami-KalajahiAbstractSmart drug-delivery systems based on stimuli-responsive polymers are extensively studied because of their advantages in controlled release of anti-cancer drugs in response to induced stimuli. To develop a smart drug-delivery system, silica nanoparticles modified with 3-(trimethoxysilyl) propyl methacrylate (MPS) were used in inverse emulsion polymerization of N,N-dimethylaminoethyl methacrylate with N,N-methylene bisacrylamide in different amounts (MBA: 2, 4, and ...
Source: Polymer - Category: Chemistry Source Type: research
Publication date: 17 August 2019Source: New Scientist, Volume 243, Issue 3243Author(s):
Source: New Scientist - Category: Science Source Type: research
This study provides new insights into understanding the molecular and cellular mechanisms involved in PBOX-induced cell death in neuroblastoma and further support s their future use as novel anti-cancer agents for the treatment of neuroblastoma.
Source: Investigational New Drugs - Category: Drugs & Pharmacology Source Type: research
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