An approach to a patient with infective endocarditis.

An approach to a patient with infective endocarditis. S Afr Med J. 2016 Feb;106(2):145-50 Authors: Hitzeroth J, Beckett N, Ntuli P Abstract Although infective endocarditis (IE) is relatively uncommon, it remains an important clinical entity with a high in-hospital and 1-year mortality. It is most commonly caused by viridans streptococci. Staphylococcus aureus is responsible for a malignant course of IE and often requires early surgery to eradicate. Other rarer causes are various bacilli, including the HACEK (Haemophilus, Actinobacillus,Cardiobacterium, Eikenella and Kingella spp.) group of organisms and fungi. The clinical presentation varies. Patients may present with a nonspecific illness, valve dysfunction, heart failure (HF) and symptoms due to peripheral embolisation. The diagnosis is traditionally based on the modified Duke criteria and rests mainly on clinical features and to a lesser extent on certain laboratory findings,microbiological assessment and cardiovascular imaging. Identification of the offending micro-organism is not only important from a diagnostic point of view, but also makes targeted antibiotic treatment possible and provides useful prognostic information. A significant proportion of microbiological cultures are negative, frequently owing to the administration of antibiotics prior to appropriate culture.Blood-culture-negative IE poses significant diagnostic and treatment challenges. The course of the disease is frequently complicate...
Source: South African Medical Journal - Category: African Health Tags: S Afr Med J Source Type: research

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CONCLUSIONS: MHR may be a significant and independent predictor of poor functional outcome in patients with AIS. PMID: 31941849 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Conclusions The analysis showed that low-frequency repetitive transcranial magnetic stimulation has a positive effect on grip strength and lower limb function as assessed by FMA.
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
Her words hung in the hushed air.“Thank you for saving our boy,” the mother said, her voice choked by emotion.Devra Schwartz, and her husband, Jeff, recently had a chance to express their gratitude to eight of the 100 strangers whose blood donations provided a lifeline for their son, Judah, now 4. The Santa Monica youngster nearly died last year when his kidneys failed due to foodborne E. coli infection.Toxins in the E. coli bacteria ruptured Judah ’s red blood cells, leading to massive blood loss. His platelets — critical to clotting and preventing hemorrhage — plummeted to 13,000. A healthy ...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
Publication date: Available online 17 January 2020Source: PhytomedicineAuthor(s): Rui Guo, Ningning Liu, Hao Liu, Junhua Zhang, Han Zhang, Yingchao Wang, Mirko Baruscotti, Lu Zhao, Yi WangAbstractBackground: Cardiac hypertrophy is a prominent feature of heart remodeling, which may eventually lead to heart failure. Tongmaiyangxin (TMYX) pills is a clinically used botanical drug for treating multiple cardiovascular diseases including chronic heart failure. The aim of the current study was to identify the bioactive compounds in Tongmaiyangxin pills that attenuate cardiomyocytes hypertrophy, and to investigate the underlying m...
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
This study showed that ATR-FTIR technique may be an alternative method for rapid detection of low-level vancomycin-resistantS. aureus.
Source: World Journal of Microbiology and Biotechnology - Category: Microbiology Source Type: research
Siegfried Richtsteig has been waiting in hospital for more than 130 days for a heart that would allow him to do the things he enjoyed most, like playing with his grandchildren, before a stroke damaged the organ beyond repair.Reuters Health Information
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Transplantation News Source Type: news
Publication date: May 2020Source: Materials Science and Engineering: C, Volume 110Author(s): Kamal Malhotra, Sudha Shankar, Neelam Chauhan, Rajkishor Rai, Yashveer SinghAbstractSelf-assembled peptide gels have generated interest as antibacterial materials to prevent biomaterial-related infections but these peptides are often associated with poor proteolytic stability. Efforts have been made to stabilize peptides by incorporating non-natural amino acids and/or linkages but complexation with polymers have not been explored. Therefore, we developed self-assembled peptide/chitosan gels, Boc-D-Phe-γ4-L-Phe-PEA (NH007)/chi...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
Publication date: Available online 16 January 2020Source: NeuroscienceAuthor(s): Cao yuze, Zhang huixue, Lu xiaoyu, Wang Jianjian, Zhang xiaoming, Sun shengnan, Bao zhonglei, Tian wenqi, Ning shangwei, Wang lihua, Cui liyingAbstractThe nucleotide oligomerization domain (NOD)-like receptor (NLR) pyrin domain-containing protein 1 (NLRP1) inflammasome has been shown to contribute to brain injury after ischemic stroke. Our previous study showed that microRNA-9a-5p (miR-9a-5p) ameliorates ischemic injury by regulating neuronal autophagy in rats subjected to middle cerebral artery occlusion (MCAO) surgery. The aims of this study...
Source: Neuroscience - Category: Neuroscience Source Type: research
ConclusionsMinimally invasive reoperative AVR with a sutureless or rapid-deployment prosthesis is a safe and feasible treatment strategy, resulting in fast recovery and improved postoperative outcome with no mortality and an acceptable complication rate.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Cloete E, Gentles TL, Bloomfield FH Abstract The mortality risk for infants with critical congenital heart disease (CCHD) unrecognised at the time of birth is high. Pulse oximetry has been utilised as a screening tool for the detection of these anomalies in the newborn as the majority will have a degree of hypoxaemia. This screening strategy has a moderate sensitivity and excellent specificity for the detection of CCHD, and a low false-positive rate. Respiratory and infective diseases are responsible for a large number of positive test results. The early recognition of these diseases can also improve healt...
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
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