Epidemiology, Clinical and Microbiologic Profile and Risk Factors for Inpatient Mortality in Pediatric Severe Sepsis in the United States From 2003 to 2014: A Large Population Analysis
OBJECTIVE: To evaluate the national trends in pediatric severe sepsis in the United States from 2003 to 2014. STUDY DESIGN: For this study, we included nonoverlapping years of Kids Inpatient database and National Inpatient Sample database while including hospitalizations of children between 1 and 20 years of age from more than 4200 hospitals across the United States. We identified patient hospitalizations with severe sepsis using specific ICD codes and modified Angus Criteria. Trend analysis of various factors associated with severe sepsis was calculated using the Cochrane-Armitage test. Associated foci of infection and co...
Source: Current Awareness Service for Health (CASH) - September 3, 2020 Category: Consumer Health News Source Type: news

Drug vignettes: Remdesivir, CEBM
The results of the compassionate-use programme for remdesivir suggest, but do not prove, that the benefits of remdesivir may outweigh the harms it might cause. It is reminiscent of the early case reports of the success of penicillin in infective endocarditis. However, the mortality rate from COVID-19 is, by the standards of acute infective endocarditis, relatively low, and so an open, uncontrolled trial will never be able to define the benefits or harms. In human subjects, the results of randomized, controlled trials have yet to show that remdesivir affects mortality in the short-term, although one study did show that pat...
Source: Current Awareness Service for Health (CASH) - August 10, 2020 Category: Consumer Health News Source Type: news

Hydromorphone-CR Exposure Ups Heart Infection Risk in PWID
FRIDAY, Jan. 31, 2020 -- Exposure to controlled-release hydromorphone, an opioid that can be abused through crushing and injection, is associated with an increased risk for infective endocarditis among people who inject drugs, according to a study... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 31, 2020 Category: Pharmaceuticals Source Type: news

Should We Worry About Bicuspid Aortic Valve?
Discussion The aortic valve usually has 3 leaflets. In bicuspid aortic valve (BAV) there are 2 asymmetric leaflets with a fish-mouthed orifice between them which may not open fully. It occurs in about 0.5-2% of the population making it one of the most common congenital heart anomalies and the most common one in adults. Transmission is autosomal dominant yet males are more likely to have BAV, indicating potential reduced penetrance in females. “BAVs are different, however, in that the tissue pathology is not limited to the valves’ leaflets but extends from the left ventricular outflow tract to the ascending thor...
Source: PediatricEducation.org - January 27, 2020 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Rising burden of hospitalisations for infective endocarditis in US
(Source: PharmacoEconomics and Outcomes News)
Source: PharmacoEconomics and Outcomes News - January 1, 2020 Category: Drugs & Pharmacology Source Type: news

Knowledge and Compliance of Dentists' and Dental Students' With Respect to Relevant Guidelines for Prescribing Antibiotic Prophylaxis for the Prevention of Infective Endocarditis: A Systematic Review
ConclusionKnowledge levels of guidelines for antibiotic prophylaxis varied greatly depending on the study design, respondent characteristics, and time period factors. There is a lack of research published on compliance rates for dentists and dental students with respect to guidelines for the prevention of infective endocarditis. (Source: Dental Technology Blog)
Source: Dental Technology Blog - December 20, 2019 Category: Dentistry Source Type: news

Endocarditis After Transcatheter Aortic Valve Implantation Endocarditis After Transcatheter Aortic Valve Implantation
Infective endocarditis after TAVI is a potentially life-threatening complication. This commentary highlights the need for increased efforts to improve its prevention, diagnosis, and treatment.European Heart Journal (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - November 13, 2019 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Substance Use Disorder Ups Risk for Death After IE Valve Surgery
TUESDAY, Oct. 22, 2019 -- Patients with infective endocarditis (IE) and substance use disorder (SUD) have a more than twofold risk for dying following valve surgery compared with patients without SUD, according to a study published online Oct. 16 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 22, 2019 Category: Pharmaceuticals Source Type: news

Public Outcomes Reporting Tied to Drop in Valve Replacements
MONDAY, Oct. 21, 2019 -- Initiating public reporting was associated with a significant decrease in valve surgery for all infective endocarditis (IE) cases, regardless of injection drug use (IDU) status, according to a study published Oct. 10 in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - October 21, 2019 Category: Pharmaceuticals Source Type: news

A Blood Filter Fights Deadly Inflammatory Response
A new blood filtration technology may prove to be life-saving for patients whose normally healthy inflammatory response to injury or illness has gone into overdrive, resulting in fatally high levels of cytokines in their blood. In an interview with MD+DI, Dr. Phillip Chan, MD, PhD, CEO of CytoSorbents Corp., explained that inflammation, and the production of substances called cytokines that drive inflammation, are the body’s natural response to heal injury or infection. But sometimes, the inflammatory response is so severe in such conditions as sepsis and infection, burn injuries, trauma, pancreatitis, li...
Source: MDDI - October 9, 2019 Category: Medical Devices Authors: Susan Shepard Tags: Cardiovascular Source Type: news

2002 to 2016 Saw Rise in Drug Abuse-Linked Infective Endocarditis
WEDNESDAY, Sept. 18, 2019 -- The incidence of infective endocarditis (IE) associated with drug abuse (DA) increased from 2002 to 2016 in the United States, with increases seen in all regions, according to a study published online Sept. 18 in the... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - September 18, 2019 Category: Pharmaceuticals Source Type: news

Valvular Heart Disease
series:Cardiovascular MedicineThis book provides up-to-date and user-friendly guidance on the evaluation, diagnosis, and treatment of heart and vascular disease. Chapters cover a broad range of issues related to valve disease, including rheumatic fever, aortic root dilatation, infective endocarditis, and heart disease in pregnancy. The physical examination of major valve lesions, imaging techniques, and choosing a balance ... (Source: Springer Medicine titles)
Source: Springer Medicine titles - August 31, 2019 Category: Databases & Libraries Tags: Cardiology Source Type: news

Infective Endocarditis Prevalence 26 Percent in Patients With E. faecalis
MONDAY, July 8, 2019 -- The prevalence of infective endocarditis (IE) is about 26 percent among patients with Enterococcus faecalis bacteremia, according to a study published in the July 16 issue of the Journal of the American College of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 8, 2019 Category: Pharmaceuticals Source Type: news

Quick sepsis-related organ failure assessment score as a possible predictor for in-hospital adverse events in infective endocarditis.
Infective endocarditis (IE) can be life-threatening because of various associated adverse events. The quick Sepsis-related Organ Failure Assessment (qSOFA) score is a straightforward useful method for predicting in-hospital mortality in patients with suspected infections. However, few data exist regarding the clinical impact of the qSOFA score on predicting adverse events in IE during hospitalization. We studied the usefulness of qSOFA score for predicting in-hospital adverse events in patients with IE. These results showed that high qSOFA score was significantly associated with in-hospital adverse events in IE patients, a...
Source: Current Awareness Service for Health (CASH) - May 29, 2019 Category: Consumer Health News Source Type: news

AHA Abx Prophylaxis Guidelines Hit Moderate-Risk Target AHA Abx Prophylaxis Guidelines Hit Moderate-Risk Target
A Canadian analysis suggests the guidelines on antibiotic prophylaxis are having their intended effect, but also identified increasing rates of infective endocarditis it says are unrelated.Medscape Medical News (Source: Medscape Cardiology Headlines)
Source: Medscape Cardiology Headlines - May 10, 2019 Category: Cardiology Tags: Cardiology News Source Type: news

Knowledge and compliance of dentists ’ and dental students’ with respect to relevant guidelines for prescribing antibiotic prophylaxis for the prevention of infective endocarditis: A systematic review.
ConclusionKnowledge levels of guidelines for antibiotic prophylaxis varied greatly depending on study design, respondent characteristics and time period factors. There is a lack of research published on compliance rates for dentists and dental students with respect to guidelines for the prevention of infective endocarditis. (Source: Dental Technology Blog)
Source: Dental Technology Blog - February 18, 2019 Category: Dentistry Source Type: news

Increasing Stroke Tied to Injectable Opioids, Endocarditis Increasing Stroke Tied to Injectable Opioids, Endocarditis
The dramatic increase over the last decade in US hospitalizations for stroke from injectable drug-related infective endocarditis coincides with the surge in opioid misuse, new research suggests.Medscape Medical News (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - January 31, 2019 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Infective Endocarditis Related to Injection Drug Use Rising
WEDNESDAY, Jan. 30, 2019 -- The risk for infective endocarditis related to injection drug use increased from 2006 to 2015, according to a study published online Jan. 28 in CMAJ, the journal of the Canadian Medical Association. Matthew A. Weir, M.D.,... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - January 30, 2019 Category: Pharmaceuticals Source Type: news

Opioid injecting linked to substantial rise in bacterial heart infections
(Canadian Medical Association Journal) A study of people who inject drugs found a significant increase in the risk of infective endocarditis, a serious infection of the lining of the heart, possibly linked to increasing use of the opioid hydromorphone. The study is published in CMAJ. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - January 28, 2019 Category: International Medicine & Public Health Source Type: news

Injection of opioids linked to significant increase in bacterial heart infections
(Lawson Health Research Institute) In a new study from ICES, Lawson Health Research Institute and Western University, researchers discovered a significant rise in the risk of infective endocarditis, a serious heart infection, among Ontarians who inject drugs. When examining opioid prescriptions in the province, the research team discovered the increased risk of infective endocarditis may be related to the growing use of a specific opioid, hydromorphone. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - January 28, 2019 Category: Infectious Diseases Source Type: news

Drug Use-Associated Infective Endocarditis Up 2007 to 2017
WEDNESDAY, Dec. 26, 2018 -- From 2007 to 2017 there was an increase in drug-use associated infective endocarditis (DUA-IE) hospitalizations and valve surgeries, according to a study published online Dec. 4 in the Annals of Internal Medicine. Asher... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - December 26, 2018 Category: Pharmaceuticals Source Type: news

Infective Endocarditis: Spike in N.C. Linked to Opioid Epidemic (CME/CE)
(MedPage Today) --'Alarming'increase prompts call to improve the related'cascade of care'(Source: MedPage Today Public Health)
Source: MedPage Today Public Health - December 5, 2018 Category: American Health Source Type: news

Infective Endocarditis: A New Consequence of the Opioid Epidemic Infective Endocarditis: A New Consequence of the Opioid Epidemic
A'staggering increase'in the occurrence of drug use-associated infective endocarditis is reported in a new study.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 4, 2018 Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news

Opioid Crisis Linked to Spike in Infective Endocarditis
(MedPage Today) -- Ten-fold rise in one state prompts urgent call for action (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - December 3, 2018 Category: Psychiatry Source Type: news

AHA: After 2007 Recs, Increase Seen in Infective Endocarditis
TUESDAY, Nov. 6, 2018 -- Following the 2007 American Heart Association (AHA) update of recommendations for antibiotic prophylaxis (AP) to prevent infective endocarditis (IE), there has been a decrease in AP and an increase in IE incidence for... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - November 6, 2018 Category: Pharmaceuticals Source Type: news

NICE should change antibiotic guidelines for dental patients -- study shows
(University of Sheffield) New research has revealed the impact a change in US guidelines had on the prescribing of antibiotic prophylaxis (AP) to prevent a life-threatening heart condition infective endocarditis (IE) in patients before undergoing invasive dental treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 5, 2018 Category: International Medicine & Public Health Source Type: news

Oral Antibiotics for Infective Endocarditis: Time to Switch? Oral Antibiotics for Infective Endocarditis: Time to Switch?
The standard of care for endocarditis for many years has been IV antibiotics, even though many patients don't complete the full treatment. Would oral antibiotics work just as well?Medscape Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 31, 2018 Category: Consumer Health News Tags: Infectious Diseases Commentary Source Type: news

Wearable Woes; Mini-Pacer for Mice; Infective Endocarditis Test
(MedPage Today) -- Recent developments of interest in cardiovascular medicine (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - October 15, 2018 Category: Cardiology Source Type: news

Surgery Questioned for Post-TAVR Infective Endocarditis
(MedPage Today) -- Amid unknowns surrounding IE after TAVR, a push for " endocarditis team " (Source: MedPage Today Infectious Disease)
Source: MedPage Today Infectious Disease - August 31, 2018 Category: Infectious Diseases Source Type: news

Infective Endocarditis Risk From Invasive Dental Procedures Infective Endocarditis Risk From Invasive Dental Procedures
Controversy remains surrounding antibiotic prophylaxis for prevention of infective endocarditis in patients undergoing invasive dental procedures. What will it take to finally settle the debate?Circulation (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 31, 2018 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Several Invasive Procedures Linked to Infective Endocarditis
WEDNESDAY, Aug. 1, 2018 -- Several invasive medical procedures, including cardiovascular procedures and procedures of the skin and management of wounds, are associated with increased risk of infective endocarditis, according to a study published in... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - August 1, 2018 Category: Pharmaceuticals Source Type: news

Infective Endocarditis More Common with Valve Issues
MONDAY, July 30, 2018 -- Individuals with bicuspid aortic valve (BAV) and mitral valve prolapse (MVP) have a higher risk of developing infective endocarditis (IE) than the general population, according to a study published in the June 19 issue of... (Source: Drugs.com - Pharma News)
Source: Drugs.com - Pharma News - July 30, 2018 Category: Pharmaceuticals Source Type: news

Infective Endocarditis Risk Still High After Invasive Procedures Infective Endocarditis Risk Still High After Invasive Procedures
The risk climbed after a range of common nondental invasive procedures in an analysis, inviting reappraisal of current conservative antibiotic prophylaxis guidelines, at least for some procedures.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - June 26, 2018 Category: Consumer Health News Tags: Cardiology News Source Type: news

Drug-Associated Infective Endocarditis On The Rise
(MedPage Today) -- But opioid epidemic role uncertain from death certificate data studied (Source: MedPage Today Psychiatry)
Source: MedPage Today Psychiatry - June 20, 2018 Category: Psychiatry Source Type: news

Infective Endocarditis: Common After New Valve?
(MedPage Today) -- 5.2% cumulative risk over decade for left-sided heart valve replacement (Source: MedPage Today Cardiovascular)
Source: MedPage Today Cardiovascular - March 26, 2018 Category: Cardiology Source Type: news

In Infective Endocarditis, Larger Vegetation Means Greater Risk In Infective Endocarditis, Larger Vegetation Means Greater Risk
Patients with infective endocarditis and a vegetation size greater than 10 mm are at significantly increased risk of embolism and death, according to a new meta-analysis.Reuters Health Information (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - February 26, 2018 Category: Consumer Health News Tags: Medscape Today News Source Type: news

CytoSorbents wins German gov ’ t funding for CytoSorb endocarditis trial
CytoSorbents (OTC:CTSO) said this week it won funding from the German Federal Ministry of Education and Research for a randomized controlled trial exploring the use of its CytoSorb blood purification technology for treating infective endocarditis. The newly funded randomized, controlled, multi-center Remove trial aims to enroll 250 patients to explore the safety and efficacy of intraoperative CytoSorb in patients with dangerous bacterial heart valve infections during valve replacement surgeries and cardiopulmonary bypass procedures, the Monmouth, N.J.-based company said. The study’s goal is to demonstrate improv...
Source: Mass Device - December 13, 2017 Category: Medical Devices Authors: Fink Densford Tags: Blood Management Business/Financial News Cardiovascular Clinical Trials CytoSorbents Corp. Source Type: news

Not All Streptococcal Bacteremia Cases Merit Echocardiography Not All Streptococcal Bacteremia Cases Merit Echocardiography
A simple score can help to determine which patients with non-beta-hemolytic streptococcal bacteremia require echocardiography to rule out infective endocarditis, researchers from Sweden report.Reuters Health Information (Source: Medscape Radiology Headlines)
Source: Medscape Radiology Headlines - October 25, 2017 Category: Radiology Tags: Infectious Diseases News Source Type: news

Bristol scientists to study oral bacteria that cause heart valve infection
Scientists at the University of Bristol are investigating how bacteria in our mouth can cause a heart problem, called infective endocarditis. Although uncommon, infective endocarditis is a serious condition that can often be fatal. (Source: University of Bristol news)
Source: University of Bristol news - August 21, 2017 Category: Universities & Medical Training Tags: Health, International, Grants and Awards, Research; Faculty of Health Sciences, Faculty of Health Sciences, Bristol Dental School; Press Release Source Type: news

Infective Endocarditis After CIED Implantation Infective Endocarditis After CIED Implantation
A recent study provides new epidemiological insights into infectious endocarditis after CIED implantation, with a focus on early signs and risk reduction.Europace (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 2, 2017 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Complicated Infective Endocarditis: A Case Series Complicated Infective Endocarditis: A Case Series
This case series illustrates some of the extracardiac complications that can arise from infective endocarditis.Journal of Medical Case Reports (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 24, 2017 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Antibiotic Prophylaxis for Infective Endocarditis Antibiotic Prophylaxis for Infective Endocarditis
The use of antibiotic prophylaxis in dentistry for prevention of infective endocarditis was once standard practice, but has become controversial in recent years. What's the current evidence?Heart (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - July 5, 2017 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Challenges in Infective Endocarditis Challenges in Infective Endocarditis
Even with optimal care, mortality from infective endocarditis is strikingly high. Why is it so challenging to treat, and what is being done to improve both prevention and outcomes?Journal of the American College of Cardiology (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - February 17, 2017 Category: Consumer Health News Tags: Cardiology Journal Article Source Type: news

Mouth bacteria can be linked to cardiovascular disease: Study
Amy WallaceFeb. 7 (UPI) -- Researchers have identified the molecular process that transports mouth bacteria into the blood stream to cause infective endocarditis, a form of heart disease. (Source: Health News - UPI.com)
Source: Health News - UPI.com - February 7, 2017 Category: Consumer Health News Source Type: news

Time to End Antibiotic Prophylaxis for Infective Endocarditis? Time to End Antibiotic Prophylaxis for Infective Endocarditis?
Dr Amal Mattu questions whether we should continue to provide antibiotic prophylaxis to patients who are undergoing various medical procedures.Medscape Emergency Medicine (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - December 2, 2016 Category: Surgery Tags: Emergency Medicine Viewpoint Source Type: news

Study Identifies Risk Factors for Infective Endocarditis After Transcatheter Aortic Valve Replacement (FREE)
By Amy Orciari Herman Edited by David G. Fairchild, MD, MPH, and Lorenzo Di Francesco, MD, FACP, FHM A new JAMA study may help clinicians identify patients who are at increased risk for infective endocarditis after transcatheter aortic valve … (Source: Physician's First Watch current issue)
Source: Physician's First Watch current issue - September 14, 2016 Category: Primary Care Source Type: news

Risk factors, clinical outcomes of infective endocarditis after transcatheter aortic valve replacement
Among patients undergoing transcatheter aortic valve replacement, younger age, male sex, history of diabetes mellitus, and moderate to severe residual aortic regurgitation were significantly associated with an increased risk of infective endocarditis, and patients who developed endocarditis had high rates of in-hospital mortality and 2-year mortality, according to a study. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - September 13, 2016 Category: Science Source Type: news

Risk factors and clinical outcomes of infective endocarditis after transcatheter aortic valve replac
(The JAMA Network Journals) Among patients undergoing transcatheter aortic valve replacement, younger age, male sex, history of diabetes mellitus, and moderate to severe residual aortic regurgitation were significantly associated with an increased risk of infective endocarditis, and patients who developed endocarditis had high rates of in-hospital mortality and 2-year mortality, according to a study appearing in the Sept. 13 issue of JAMA. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 13, 2016 Category: Global & Universal Source Type: news

Sep 9 Cardiology News Sep 9 Cardiology News
Trends in infective endocarditis, vein-graft intervention, use of OCT in ACS, hypertrophic cardiomyopathy, and electronic health records are discussed in this week's podcast.theheart.org on Medscape (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - September 9, 2016 Category: Consumer Health News Tags: Cardiology News Source Type: news