Heat shock factor-1 knockout enhances cholesterol 7{alpha}-hydroxylase (CYP7A1) and multidrug transporter (MDR1) gene expressions to attenuate atherosclerosis

Conclusion
HSF-1 ablation not only eliminates heat shock response, but it also transcriptionally up-regulates CYP7A1 and MDR1/P-gp axis in WD-diet fed HSF-1–/–/LDLr–/– mice to reduce atherosclerosis.

Source: Cardiovascular Research - June 14, 2016 Category: Cardiology Authors: Krishnamurthy, K., Glaser, S., Alpini, G. D., Cardounel, A. J., Liu, Z., Ilangovan, G. Tags: Vascular Biology Source Type: research