Affective responses across psychiatric disorders—A dimensional approach

Publication date: 3 June 2016 Source:Neuroscience Letters, Volume 623 Author(s): Claudia Hägele, Eva Friedel, Florian Schlagenhauf, Philipp Sterzer, Anne Beck, Felix Bermpohl, Meline Stoy, Dada Held-Poschardt, André Wittmann, Andreas Ströhle, Andreas Heinz Studying psychiatric disorders across nosological boundaries aims at a better understanding of mental disorders by identifying comprehensive signatures of core symptoms. Here, we studied neurobiological correlates of emotion processing in several major psychiatric disorders. We assessed differences between diagnostic groups, and investigated whether there is a psychopathological correlate of emotion processing that transcends disorder categories. 135 patient with psychiatric disorders (alcohol dependence, n=29; schizophrenia, n=37; major depressive disorder (MDD), n=25; acute manic episode of bipolar disorder, n=12; panic disorder, n=12, attention deficit/hyperactivity disorder (ADHD), n=20) and healthy controls (n=40) underwent an functional magnetic resonance imaging (fMRI) experiment with affectively positive, aversive and neutral pictures from the International Affective Picture System (IAPS). Between-group differences were assessed with full-factorial ANOVAs, with age, gender and smoking habits as covariates. Self-ratings of depressed mood and anxiety were correlated with activation clusters showing significant stimulus-evoked fMRI activation. Furthermore, we examined functional connectivit...
Source: Neuroscience Letters - Category: Neuroscience Source Type: research