Editorial.

Editorial. Cell Mol Biol (Noisy-le-grand). 2015;61(6):1 Authors: Farooqi AA, Ismail M Abstract Cancer is a multifaceted disease and research over decades has sequentially broadened our understanding of the mechanisms which underlie its development, progression and resistance against wide ranging molecular therapeutics. Data obtained through in—vitro studies and xenografted mice based investigations clearly suggested that inactivation of tumor suppressor genes, overexpression of oncogenes, imbalance of pro— and anti—apoptotic proteins, loss of apoptosis, dysregulation of spatio—temporally controlled intracellular signaling cascades, epithelial to mesenchymal transition, intra—tumor heterogeneity are significantly involved in regulation of different steps of cancer. Recently emerging information is also shedding light on considerable role of microRNAs in cancer and we have seen an exponential growth in the list of tumor suppressor and oncogenic miRNAs. Amirkhah et al, described how miRNAs regulated resistance mechanisms against different therapeutics in colorectal cancer. Nosheen Masood and Muhammad Zahid Qureshi emphasized on intricate interplay between Notch signaling and different miRNAs in head and neck cancer. Gasparri et al discussed new frontiers in therapeutic targets in ovarian cancer with spotlight on PARP inhibitors. Notch mediated intracellular signaling in esophageal cancer...
Source: Cellular and Molecular Biology - Category: Molecular Biology Tags: Cell Mol Biol (Noisy-le-grand) Source Type: research