After UCLA-led tests, immunotherapy drug approved by FDA to treat lung cancer

Pembrolizumab, a drug that has already been proven to extend the lives of people with advanced melanoma, has now been approved by the U.S. Food and Drug Administration to treat advanced non-small cell lung cancer. The study, the largest published research to date using immunotherapy to treat lung cancer, was conducted at UCLA and 29 other sites in the U.S., Europe and Australia. “The approval of this drug and a test to identify patients most likely to benefit has the potential to transform the way that lung cancer is treated,” said Dr. Edward Garon, the study’s principal investigator and a researcher at UCLA’s Jonsson Comprehensive Cancer Center. “The quality and duration of disease response that was seen in the trial had previously been extremely rare in lung cancer. For people battling this deadly disease, this approach provides real hope of long-lasting responses while avoiding the toxicities of typical chemotherapy.” The drug, which is marketed under the brand name Keytruda, was tested on approximately 500 patients with non-small cell lung cancer. Because so many of the patients in the study showed significant long-lasting responses, in October 2014 the FDA granted the drug “breakthrough therapy” status for use in lung cancer, allowing it to be fast-tracked for approval. Keytruda is an antibody that targets the protein PD-1, which is expressed by immune cells. When it binds to the another protein called PD-L1, PD-1 acts as a...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news

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We report energy band bending of methylammonium lead halide (MAPbI3) perovskite film in contact with indium-tin-oxide (ITO) surface using photoelectron spectroscopy in air (PESA) and ultraviolet photoelectron spectroscopy (UPS) measurements. MAPbI3 perovskite films were vacuum-deposited using co-evaporation of methylammonium iodide (CH3NH3I, MAI) and lead iodide (PbI2) powders. Using PESA and UPS, the highest occupied molecular orbital levels were measured varying the thickness of the perovskite films. Substantial energy band bending close to the ITO surface was not observed. The vacuum-deposited perovskite films feature a...
Source: Results in Physics - Category: Physics Source Type: research
Publication date: Available online 21 September 2018Source: Results in PhysicsAuthor(s): H.H. Zhang, Y. Chen, Z. ZhangAbstractTwo benzaldehyde thiosemicarbazone derivatives namely 3-methoxy,4-hydroxyl-benzaldehyde thiosemicarbazone (MHBT) and 2-hydroxyl,3-methoxy-benzaldehyde thiosemicarbazone (HMBT) were synthesized and their inhibition behavior for mild steel in 1.0 M HCl solution was investigated using gravimetric measurements and electrochemical tests. Weight loss measurements suggested that these two compounds acted as efficient inhibitors for mild steel in 1.0 M HCl solution and the inhibition efficiency reached a ma...
Source: Results in Physics - Category: Physics Source Type: research
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Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
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Source: Biosensors and Bioelectronics - Category: Biotechnology Source Type: research
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Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
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Source: Sensors and Actuators B: Chemical - Category: Chemistry Source Type: research
From portable genome sequencers until genetic tests revealing distant relations with Thomas Jefferson, genomics represents a fascinatingly innovative area of healthcare. As the price of genome sequencing has been in free fall for years, the start-up scene is bursting from transformative power. Let’s look at some of the most amazing ventures in genomics! The amazing journey of genome sequencing Genome sequencing has been on an amazing scientific as well as economic journey for the last three decades. The Human Genome Project began in 1990 with the aim of mapping the whole structure of the human genome and sequencing ...
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By Stacy SimonThe US Food and Drug Administration (FDA) has approved Keytruda (pembrolizumab) to treat people with head and neck squamous cell carcinoma that has spread or come back after previous chemotherapy treatment. It’s the first immunotherapy drug approved for head and neck cancer. Keytruda is already approved for melanoma and non-small cell lung cancer.The FDA based its approval on a clinical trial of 174 people with head and neck squamous cell carcinoma that had spread or come back after they were treated with platinum-based chemotherapy. Tumors shrank or disappeared in 16% of the participants who were given...
Source: American Cancer Society :: News and Features - Category: Cancer & Oncology Tags: Oral Cavity and Oropharyngeal Cancer Source Type: news
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