Abstract 1428: Targeting RRM2 by siRNA inhibits cellular invasion and represents a rational approach for inhibition of metastasis of head and neck and lung cancers

Conclusions: Our study demonstrated that RRM2 substantially promoted cell invasion by stabilizing Twist 1 and suppressing E-Cadherin. Thus, an elevated RRM2 may serve as a potential biomarker for metastasis of HNSCC and NSCLC. Targeting RRM2 and its downstream signaling intermediaries may represent a rational approach for developing novel anticancer therapeutics. We are in the process of conducting an animal study to validate the strategy of silencing of RRM2 by using RRM2-siRNA nanoparticle to inhibit metastasis. (This work is supported by grants from NIH U01CA151802, P50CA128613).Citation Format: Mohammad Aminur Rahman, A.R.M. Ruhul Amin, Jun Zhang, Sreenivas Nannapaneni, Nabil F. Saba, Zhuo Georgia Chen, Dong M. Shin. Targeting RRM2 by siRNA inhibits cellular invasion and represents a rational approach for inhibition of metastasis of head and neck and lung cancers. [abstract]. In: Proceedings of the 106th Annual Meeting of the American Association for Cancer Research; 2015 Apr 18-22; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Res 2015;75(15 Suppl):Abstract nr 1428. doi:10.1158/1538-7445.AM2015-1428

Source: Cancer Research - August 2, 2015 Category: Cancer & Oncology Authors: Rahman, M. A., Amin, A. R. M. R., Zhang, J., Nannapaneni, S., Saba, N. F., Chen, Z. G., Shin, D. M. Tags: Tumor Biology Source Type: research