The Biomedical Advanced Research and Development Authority Special Projects

Funding Opportunity Number: EP-IDS-15-002 Opportunity Category: DiscretionaryFunding Instrument Type: Cooperative AgreementCategory of Funding Activity: HealthCFDA Number: 93.360Eligible Applicants State governmentsCounty governmentsCity or township governmentsSpecial district governmentsPublic and State controlled institutions of higher educationNative American tribal governments (Federally recognized)Native American tribal organizations (other than Federally recognized tribal governments)Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher educationNonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher educationPrivate institutions of higher educationIndividualsFor profit organizations other than small businessesSmall businessesOthers (see text field entitled "Additional Information on Eligibility" for clarification)Agency Name: HHS-OS-ASPRClosing Date: Sep 04, 2015Award Ceiling: $200,000Expected Number of Awards: 1Creation Date: Jul 06, 2015Funding Opportunity Description: The Biomedical Advanced Research and Development Authority (BARDA), within the Office of the Assistant Secretary for Preparedness and Response (ASPR) in the U.S. Department of Health and Human Services (HHS), supports advanced development and availability of medical countermeasures (MCMs) for chemical, biological, radiological and nuclear (CBRN) threats, pandemic influenza, and emerging infectious diseases ...
Source: Grants.gov - Category: Research Tags: Health Source Type: funding

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Abstract While the opioid epidemic has garnered significant attention, the use of methamphetamines is growing worldwide independent of wealth or region. Following overdose and accidents, the leading cause of death in methamphetamine users is cardiovascular disease, because of significant effects of methamphetamine on vasoconstriction, pulmonary hypertension, atherosclerotic plaque formation, cardiac arrhythmias, and cardiomyopathy. In this review, we examine the current literature on methamphetamine-induced changes in cardiovascular health, discuss the potential mechanisms regulating these varied effects, and high...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
In conclusion, shift workers in health care had more ILI/ARI episodes and more severe ILI/ARI episodes than non–shift workers, but with a similar duration. Insight into underlying mechanisms connecting shift work and in fection susceptibility will contribute to the design of preventive initiatives.
Source: American Journal of Epidemiology - Category: Epidemiology Source Type: research
Authors: Yoo IY, Kang OK, Shim HJ, Huh HJ, Lee NY Abstract As various linezolid resistance mechanisms have been identified in methicillin-resistant Staphylococcus aureus (MRSA), we investigated the molecular characteristics of MRSA with elevated linezolid minimum inhibitory concentrations (MICs), using the VITEK 2 system (bioMérieux, Marcy-l'Étoile, France). Twenty-seven MRSA isolates from 14 patients exhibiting linezolid MICs ≥8 μg/mL were examined by broth microdilution (BMD) test as well as by sequencing for mutations in the 23S rRNA gene or ribosomal proteins (L3, L4, and L22) and the presen...
Source: Annals of Laboratory Medicine - Category: Laboratory Medicine Tags: Ann Lab Med Source Type: research
In this study, we targeted a highly conserved region of these proteins by an antisense sequence that was covalently conjugated to the cell penetrating peptides (CPP) to overcome the challenging delivery barriers. Then, we evaluated the efficiency of this construct in vitro. We also assessed the antigenicity, cytotoxicity, and probability of apoptosis induction by this construct.The studied CPP-PNA inhibited bacterial growth and suppressed the mRNA expression of internalins in a dose-dependent manner. In addition, at all studied concentrations, CPP-PNA significantly reduced the invasion rate of L. monocytogenes in the exami...
Source: Microbial Pathogenesis - Category: Infectious Diseases Source Type: research
Publication date: September 2019Source: Journal of Global Antimicrobial Resistance, Volume 18Author(s): Tanya Strateva, Slavil Peykov, Ivo Sirakov, Encho Savov, Svetoslav Dimov, Ivan Mitov
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionThe sequenced genome revealed interesting aspects related to antibiotic resistance dissemination. The ARI are more stable in the genome and the chance of losing it is less probable, with the possibility of the described transposon to re-integrate in other plasmids, facilitating the dissemination of such resistance determinants.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
This study aimed to describe the preparation and in vitro evaluation of a surface-modified nanostructured lipid carrier (NLC) using chitosan and dextran for co-delivery of buparvaquone (BPQ) and polymyxin B (PB) against leishmaniasis.MethodsThe NLC was prepared using high-pressure homogenisation. Polymyxin B binding and surface modification with biopolymers were achieved by electrostatic interaction. In vitro cytotoxicity was assessed in mouse peritoneal macrophages, and leishmanicidal activity in amastigotes of Leishmania infantum.ResultsThe performance attributes of BPQ-NLC, BPQ-NLC-PB[A−] (anionic) and BPQ-NLC-PB[...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
This study focused on estimating the prevalence of extended-spectrum β-lactamases (ESBLs), plasmid-mediated AmpC β-lactamases, carbapenemases and MCR-1-producing Escherichia coli in canine faeces from a public park in Quito, Ecuador.MethodsPhenotypic and genotypic characterisation of E. coli isolated from 50 canine faecal samples recovered from a city park in Quito was performed. In addition, a multiple choice survey was conducted among 50 dog owners.ResultsOf the 50 faecal samples, 20 (40.0%) presented E. coli resistant to ceftriaxone. Moreover, 23 E. coli isolates were recovered for further analysis. All of the...
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
An outbreak of antibiotic linked to American beef and soft cheese imported from Mexico has sent 60 people to the hospitals. Antibiotic resistance is rare in salmonella, causing concern for the CDC.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
The mosquito-borne virus spread through the island in 2017, but global health officials failed to sound the alarm.
Source: NYT Health - Category: Consumer Health News Authors: Tags: Zika Virus Epidemics Viruses Mosquitoes Cell (Journal) Pan American Health Organization Cuba your-feed-science Source Type: news
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