Endometrial stem cells alleviate cisplatin-induced ferroptosis of granulosa cells by regulating Nrf2 expression

CONCLUSION: Our study demonstrated that cisplatin could induce ferroptosis in granulosa cells, while EnSCs could inhibit ferroptosis and thus exert repair effects on the cisplatin-induced injury model both in vivo and in vitro. Meanwhile, Nrf2 was validated to participate in this regulatory process and played an essential role.PMID:38605340 | PMC:PMC11008046 | DOI:10.1186/s12958-024-01208-8

Source: Reproductive Biology - April 11, 2024 Category: Reproduction Medicine Authors: Rumeng Pan Rongli Wang Feiyan Cheng Lihui Wang Zhiwei Cui Jing She Xinyuan Yang Source Type: research