Role Of Truncated Tropomyosin Receptor Kinase B In Oral Cancer Pain

We previously demonstrated that brain-derived neurotrophic factor (BDNF) released from oral squamous cell carcinoma (OSCC) cells orchestrate oral cancer-induced pain transmission, that is reversed by locally inhibiting its receptor, TrkB, at the site of oral tumor growth. The truncated isoform (TrkBTK-), lacking the tyrosine kinase domain, was shown to be the predominant isoform expressed in oral cancers. Therefore, our current study explores the contribution of peripheral truncated TrkB isoform in mediating oral cancer pain.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research