Sensitization Of Epidermal Transient Receptor Potential Vanilloid 4 Receptor in Paclitaxel Model of Chemotherapy-Induced Peripheral Neuropathy

Recent studies suggest that systemic inhibition of the Transient Receptor Potential Vanilloid 4 (TRPV4) cation channel or complete removal of TRPV4 globally results in significant improvements in alleviating the painful peripheral neuropathy induced by chemotherapy agents. TRPV4 is expressed in various tissues, where it plays a crucial role in normal functioning, contributing to the perception and processing of various sensory modalities, as well as the regulation of cardiovascular, respiratory, and renal functions.
Source: The Journal of Pain - Category: Materials Science Authors: Source Type: research