Cholesterol 25-hydroxylase prevents type 2 diabetes mellitus induced cardiomyopathy by alleviating cardiac lipotoxicity

CONCLUSION: Our study provides compelling evidence supporting the protective role of CH25H in T2DM-induced cardiomyopathy. Furthermore, the regulation of PGC-1α may be intricately involved in this cardioprotective process.PMID:38588780 | DOI:10.1016/j.bbadis.2024.167158

Source: Biochimica et Biophysica Acta - April 8, 2024 Category: Biochemistry Authors: Jialiang Zhang Hao Zhou Fan Lei Kexin Jiang Yanbiao Liao Fangyang Huang Mao Chen Source Type: research