Endothelial-Specific Reduction in Arf6 Impairs Insulin-Stimulated Vasodilation and Skeletal Muscle Blood Flow Resulting in Systemic Insulin Resistance in Mice

CONCLUSIONS: Results from this study support the conclusion that endothelial Arf6 signaling is essential for maintaining insulin sensitivity. Reduced expression of endothelial Arf6 impairs insulin-mediated vasodilation and results in systemic insulin resistance. These results have therapeutic implications for diseases that are associated with endothelial cell dysfunction and insulin resistance such as diabetes.PMID:38545783 | DOI:10.1161/ATVBAHA.123.319375

Source: Arteriosclerosis, Thrombosis and Vascular Biology - March 28, 2024 Category: Cardiology Authors: Md Torikul Islam Jinjin Cai Shanena Allen Denisse G Moreno Samuel I Bloom R Colton Bramwell Jonathan Mitton Andrew G Horn Weiquan Zhu Anthony J Donato William L Holland Lisa A Lesniewski Source Type: research