Glucocorticoid use and varying doses on the long-term outcomes of offspring born to patients with systemic lupus erythematosus

Conclusion: The use of non-fluorinated glucocorticoids during pregnancy and varying doses did not have a significant impact on the long-term physical, neurological, and social-emotional development outcomes of offspring born to SLE patients. However, the offspring of SLE patients treated with glucocorticoids  >  10 mg/day during pregnancy may be necessary to strengthen the monitoring of height (length) and communication skills in the long term.What is Known:• Fetal exposure to glucocorticoids can have implications for the development of multiple systems and may persist after birth, potentially increasing the risk of neurological abnormalities and other diseases.• There is limited research on the long-term development of offspring born to SLE patients, especially the patients treated with glucocorticoids.What is New:• The use of non-fluorinated glucocorticoids during pregnancy and varying doses did not have a significant impact on the long-term outcomes of offspring born to SLE patients.• The offspring of SLE patients treated with glucocorticoids>10 mg/day during pregnancy may be necessary to strengthen the monitoring of height (length) and communication skills in the long term.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research