Causal Relationships of Chronic Constipation and Irritable Bowel Syndrome with Digestive Tract Cancers: A Mendelian Randomization Study

CONCLUSION: In summary, genetically predicted constipation was associated with an augmented PAAD risk, and IBS was associated with an increased CRC susceptibility within European cohorts, in agreement with some observational studies. Nevertheless, the causal associations of constipation and IBS with other DTCs remain inconclusive.PMID:38243929 | DOI:10.2174/0115748928283326231229061358
Source: Recent Patents on Anti-Cancer Drug Discovery - Category: Cancer & Oncology Authors: Source Type: research