Multisystem inflammatory syndrome in children (MIS-C): A nationwide collaborative study in the Greek population

Conclusion: MIS-C is a novel, infrequent but serious disease entity. Cardiac manifestations included myocarditis and pericarditis, which resolved in most patients before discharge. Timely initiation of immunomodulatory therapy was shown to be effective. NT-pro-BNP levels may provide a better prediction and monitoring of the disease course. Further research is required to elucidate the pathogenesis, risk factors and optimal management, and long-term outcomes of this clinical entity.What is Known:• MIS-C is an infrequent but serious disease entity.• Patients with MIS-C present with multi-organ dysfunction, primarily involving the gastrointestinal and cardiovascular systems.What is New:• NT-pro-BNP levels may provide a better prediction and monitoring of the disease course.• Acute kidney injury and/or myocarditis were associated with higher risk of developing shock.
Source: European Journal of Pediatrics - Category: Pediatrics Source Type: research