Profiling of the genetic features of patients with breast, ovarian, colorectal and extracolonic cancers: Association to CHEK2 and PALB2 germline mutations

CONCLUSIONS: Multigene panel testing improves the chance of finding PVs in actionable genes in families with HCS. In addition, the coexistence of variants should be recorded to implement a polygenic risk algorithm that might explain the missing heritability in the aforementioned families.PMID:38061684 | DOI:10.1016/j.cca.2023.117695

Source: International Journal of Clinical Chemistry - December 7, 2023 Category: Chemistry Authors: Mar Infante M ónica Arranz-Ledo Enrique Lastra Amaya Olaverri Raquel Ferreira Marta Orozco Lara Hern ández Noem í Martínez Mercedes Dur án Source Type: research