Issue Information

Front coverThis review article explains the safety, clinical effects and mechanism of action of ropinirole in amyotrophic lateral sclerosis (ALS) in translational research (TR) and the close link between the patients and their iPSC-derived motor neurons in reverse translational research (rTR).Image contentThis cover image represents the traditional Japanese Kabuki performance “Renjishi (The Father and Son Shishi Lions in English)”. This performance is a powerful masterpiece about the love between parents and children. It shows parental ALS patients and their children, iPS cell-derived motor neurons, fighting ALS on a genetically linked pedestal. The strongly growing pine trees in the background represent the development of iPS cell drug discovery with tablets of the investigational drug ropinirole. The trousers (Hakama) are patterned with a crested tortoise shell design based on the shell of the tortoise, a symbol of longevity, with the structural formula of ro pinirole within it. On both sleeves of the child, a colony of iPS cells is depicted. Illustration: Wataru Takayanagi (LAIMAN).Read the full article‘Induced pluripotent stem cells-based disease modeling, drug screening, clinical trials, and reverse translational research for amyotrophic lateral sclerosis ’ by H. Okano, S. Morimoto, C. Kato, J. Nakahara and S. Takahashi (J. Neurochem. vol. 167(5), pp. 603 –614) on doi:10.1111/jnc.16005
Source: Journal of Neurochemistry - Category: Neuroscience Tags: ISSUE INFORMATION Source Type: research