Platinum-based chemotherapy induces demyelination of Schwann cells in oral squamous cell carcinoma treatment

CONCLUSION: Cisplatin and carboplatin, but not oxaliplatin, caused mitochondrial dysfunction and induced demyelination in RSC96 while showing similar toxicity to head and neck cancer cells. Oxaliplatin may be a potential chemotherapy drug to prevent CIPN in patients with head and neck cancer.PMID:37944569 | DOI:10.1016/j.taap.2023.116751

Source: Toxicology and Applied Pharmacology - November 9, 2023 Category: Toxicology Authors: Xian Wang Weifa Yang Leilei Wang Liwu Zheng Wing Shan Choi Source Type: research