Analysis of Fecal Microbiota in Patients with Hypertension Complicated with Ischemic Stroke

This study aims to explore whether intestinal microbes play an important role in the pathogenesis of ischemic stroke in a hypertensive population. In this study, the inpatients in the Department of Neurology and Cardiology of the Second Affiliated Hospital of Shandong First Medical University in April 2021 were selected, including seven patients with hypertension complicated with ischemic stroke and only seven patients with hypertension. After collecting the stool samples of patients, the gene sequence of the samples was detected by 16S rRNA sequencing technology, and the double-ended 2  × 150 bp sequencing was carried out. After sequencing, the results were analyzed by diversity analysis, species difference analysis, species function difference analysis, and other bioinformatics tests. According to the test results, serum proteomics and biochemical blood tests were carried o ut to verify. There was no significant difference in α diversity and β diversity between hypertension complicated with the cerebral infarction and hypertension groups. LEfSe analysis showed that at the genus level, compared with the hypertension group,Bacteroides, UCG_009, andEisenbergiella had significantly increased relative abundance. The genera with relatively significantly reduced abundance areRuminococcus_gnavus_group,Sutterellaceae,Burkholderia, andPrevotella and the LDA score ofPrevotella is  <   − 4, which indicates that there are significant differences. Compared with the b...
Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research