Bilirubin potentiates etomidate-induced sedation by enhancing GABA-induced currents after bile duct ligation

CONCLUSIONS: Our results demonstrated that pathologic bilirubin in CSF could enhance etomidate induced sedation. The mechanism may be that bilirubin increase the GABA-induced currents of rat pyramidal neurons.PMID:37740245 | PMC:PMC10517516 | DOI:10.1186/s40360-023-00675-w

Source: BMC Pharmacology and Toxicology - September 22, 2023 Category: Drugs & Pharmacology Authors: Hao Gao Qian Zhao Jian-Gang Song Guo-Xia Hu Wei-Feng Yu Ying-Fu Jiao Jin-Chao Song Source Type: research