Growth hormone receptor gene disruption
Vitam Horm. 2023;123:109-149. doi: 10.1016/bs.vh.2022.12.004. Epub 2023 Aug 24.ABSTRACTMuch of our understanding of growth hormone's (GH)'s numerous activities stems from studies utilizing GH receptor (GHR) knockout mice. More recently, the role of GH action has been examined by creating mice with tissue-specific or temporal GHR disruption. To date, 37 distinct GHR knockout mouse lines have been created. Targeted tissues include fat, liver, muscle, heart, bone, brain, macrophage, intestine, hematopoietic stem cells, pancreatic β cells, and inducible multi-tissue "global" disruption at various ages. In this chapter, a summary of each mouse line is provided with background information on the generation of the mouse line as well as important physiological outcomes resulting from GHR gene disruption. Collectively, these mouse lines provide unique insights into GH action and have resulted in the development of new hypotheses about the functions ascribed to GH action in particular tissues.PMID:37717983 | DOI:10.1016/bs.vh.2022.12.004
Source: Vitamins and Hormones - Category: Endocrinology Authors: Edward O List Silvana Duran-Ortiz Prateek Kulkarni Emily Davis Patricia Mora-Criollo Darlene E Berryman John J Kopchick Source Type: research
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