A Comparison of the Effects of Dexamethasone and Methylprednisolone, Used on Level-3 Intensive Care COVID-19 Patients, on Mortality: A Multi-Center Retrospective Study

CONCLUSION: Corticosteroids are shown to be beneficial in critical COVID-19, but the role of early corticosteroids in mild COVID-19 patients remains unclear. The anti-inflammatory effects of corticosteroids may have a positive effect by reducing mortality in severe COVID-19 patients. Although dexamethasone was first used for this purpose, methylprednisolone was found to be as effective at standard doses. Methylprednisolone administered at standard doses was associated with greater PaO2/FiO2 ratios than dexamethasone, especially in the severe group requiring MV. High dose pulse steroid doses are closely associated with mortality and standard methylprednisolone dose is recommended.PMID:37489719 | PMC:PMC10366414 | DOI:10.3346/jkms.2023.38.e232

Source: Journal of Korean Medical Science - July 25, 2023 Category: Biomedical Science Authors: Ahmet Sari Osman Ekinci Kemal Tolga Sara çoğlu Recep Bal ık Mesut Aslan Yelda Bal ık Ceren Önal Murat Aslan Semra Cevher Aylin Parmaks ız Şeule Vatansever M ünire Canan Çicek Özge Sayın Ayan Gaye Şensöz Çelik A çelya Toprak Mehmet Y ılmaz Source Type: research