Cheese consumption and multiple health outcomes: an umbrella review and updated meta-analysis of prospective studies

Adv Nutr. 2023 Jun 14:S2161-8313(23)01328-5. doi: 10.1016/j.advnut.2023.06.007. Online ahead of print.ABSTRACTThis umbrella review aims to provide a systematic and comprehensive overview of current evidence from prospective studies on the diverse health effects of cheese consumption. We searched PubMed, Embase, and Cochrane Library to identify meta-analyses/pooled analyses of prospective studies examining the associations between cheese consumption and major health outcomes from inception to August 31, 2022. We reanalyzed and updated previous meta-analyses and performed de novo meta-analyses with recently published prospective studies, where appropriate. We calculated the summary effect size, 95% prediction confidence intervals, between-study heterogeneity, small-study effects, and excess significance bias for each health outcome. We identified 54 eligible articles of meta-analyses/pooled analyses. After adding newly published original articles, we performed 35 updated meta-analyses and 4 de novo meta-analyses. Together with eight previous meta-analyses, we finally included 47 unique health outcomes. Cheese consumption was inversely associated with all-cause mortality (highest vs. lowest category: RR=0.95, 95%CI: 0.92, 0.99), cardiovascular mortality (RR=0.93, 95%CI: 0.88, 0.99), incident cardiovascular disease (CVD) (RR=0.92, 95%CI: 0.89, 0.96), coronary heart disease (CHD) (RR=0.92, 95%CI: 0.86, 0.98), stroke (RR=0.93, 95%CI: 0.89, 0.98), estrogen receptor-negative (ER-) br...
Source: Adv Data - Category: Epidemiology Authors: Source Type: research