< em > In vivo < /em > recognition of bioactive substances of < em > Polygonum multiflorum < /em > for protecting mitochondria against metabolic dysfunction-associated fatty liver disease

CONCLUSION: PM restored mitochondrial structure and function and alleviated MAFLD, which may be associated with the remedy of oxidative stress and energy production. The identified eight chemicals may be the main bioactive ingredients in PM that adjusted mitochondria to prevent MAFLD. Thus, PM provides a new approach to prevent MAFLD-related mitochondrial dysfunction. Mitochondrial pharmacology and pharmacochemistry further showed efficient strategies for determining the bioactive ingredients of Chinese medicines that adjust mitochondria to prevent diseases.PMID:36683716 | PMC:PMC9850952 | DOI:10.3748/wjg.v29.i1.171
Source: World Journal of Gastroenterology - Category: Gastroenterology Authors: Source Type: research